Description

Benzyl-Peg2-Tos CAS NO 4981-83-3 is a high-purity, functionalized polyethylene glycol (PEG) derivative featuring a benzyl protecting group and a tosylate leaving group. This bifunctional linker is critical for introducing hydrophilic spacers and enabling controlled conjugation in advanced chemical synthesis. It is primarily utilized by researchers and manufacturers in the pharmaceutical, bioconjugation, and materials science sectors for developing novel drug delivery systems, prodrugs, and functional polymers.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of antibody-drug conjugates (ADCs), peptide therapeutics, and targeted prodrugs.
• Bioconjugation Linker: Used to attach drugs, dyes, or other functional molecules to proteins, antibodies, or nanoparticles, improving solubility and pharmacokinetics.
• Polymer Chemistry: Acts as a functional initiator or monomer for creating PEG-based block copolymers, hydrogels, and smart materials.
• Surface Modification: Employed to PEGylate surfaces, particles, or medical devices to enhance biocompatibility and reduce non-specific binding.
• Chemical Biology Tool: Facilitates the study of biomolecular interactions and cellular processes through controlled labeling and cross-linking.
• Solubility Enhancer: Incorporated into drug molecules to significantly improve their aqueous solubility and bioavailability.

Basic Information

Product Name	Benzyl-Peg2-Tos
CAS No.	4981-83-3
Molecular Formula	C19H24O6S
Molecular Weight	380.45 g/mol
Synonyms	2-[2-(Benzyloxy)ethoxy]ethyl 4-methylbenzenesulfonate; PEG2-Benzyl Tosylate; α-Benzyl-ω-tosyl-pentaethylene glycol; Benzyl-PEG2-OTs; 1-Benzyloxy-3-(p-toluenesulfonyloxy)-2,5,8-trioxanonane; 3,6-Dioxa-9-(phenylmethoxy)-1-(p-toluenesulfonyloxy)nonane; Benzyl-triethylene glycol tosylate; Bn-PEG2-OTs
EINECS	Contact for details

Quality Control

Our Benzyl-Peg2-Tos is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity suitable for sensitive research and GMP-grade applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This compound is hygroscopic (moisture-sensitive); containers should be sealed under inert atmosphere or with desiccant after opening to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.