Description

Clofibrylglycine is a significant organic compound and a key metabolite of the lipid-regulating agent clofibrate. This high-purity intermediate is essential for research and development in pharmaceutical synthesis, particularly in the study of drug metabolism and pharmacokinetics. It is primarily utilized by pharmaceutical R&D laboratories, analytical reference standard producers, and manufacturers of active pharmaceutical ingredients (APIs) requiring precise and reliable chemical building blocks.

Application

• Pharmaceutical Reference Standard: Serves as a critical certified reference material (CRM) for the analytical quantification of clofibrate and its metabolites in biological matrices.
• Metabolite Research: Used in preclinical and clinical studies to investigate the metabolic pathways, bioavailability, and excretion profiles of fibrate-class drugs.
• Active Pharmaceutical Ingredient (API) Synthesis: Acts as a high-purity intermediate or starting material in the synthesis of novel pharmaceutical compounds targeting lipid metabolism.
• Biochemical Research: Employed in in-vitro assays to study the mechanism of action and enzymatic interactions related to peroxisome proliferator-activated receptors (PPARs).
• Quality Control & Method Development: Essential for developing and validating analytical methods (e.g., HPLC, LC-MS/MS) in pharmaceutical quality control laboratories.

Basic Information

Product Name	Clofibrylglycine
CAS No.	4896-55-3
Molecular Formula	C11H12ClNO3
Molecular Weight	241.67 g/mol
Synonyms	2-(4-Chlorophenoxy)-2-methylpropanoic acid glycine conjugate; Clofibric acid glycine conjugate; N-(2-(4-Chlorophenoxy)-2-methylpropanoyl)glycine; Clofibrate metabolite; CPGA; 4-Chlorophenoxyisobutyrylglycine
EINECS	Contact for details

Quality Control

Our Clofibrylglycine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including identification by IR and NMR, purity assay by HPLC, and control of specific impurities, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.