Description

7-Monodemethyl Minocycline is a key intermediate and active pharmaceutical ingredient (API) metabolite derived from the tetracycline-class antibiotic minocycline. This compound is of significant value in pharmaceutical research and development, particularly for studying drug metabolism, pharmacokinetics, and for use as a reference standard. It is primarily sought after by research institutions, analytical laboratories, and pharmaceutical manufacturers engaged in the development, quality control, and bioequivalence studies of tetracycline-based therapeutics.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified reference material (CRM) for analytical methods including HPLC, LC-MS, and UV in quality control laboratories.
• Metabolite Research: Critical for in-vitro and in-vivo studies investigating the metabolic pathways, efficacy, and safety profile of minocycline.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a sophisticated building block in the synthesis and development of novel tetracycline derivatives.
• Bioanalytical Assay Development: Essential for calibrating equipment and validating methods in pharmacokinetic and bioequivalence studies.
• Impurity Profiling: Employed to identify, quantify, and monitor related substances in minocycline API and finished drug products to ensure compliance with pharmacopeial standards (USP, EP).
• Academic and Clinical Research: Supports fundamental research into the mechanisms of action and resistance of tetracycline antibiotics.

Basic Information

Product Name	7-Monodemethyl Minocycline
CAS No.	4708-96-7
Molecular Formula	C22H27N3O7
Molecular Weight	445.47 g/mol
Synonyms	7-Demethylminocycline; 7-Demethyl Minocycline; 7-Desmethylminocycline; Minocycline Impurity C; Minocycline Metabolite; 4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide; U-42,126E
EINECS	Contact for details

Quality Control

Our 7-Monodemethyl Minocycline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by IR and MS, to ensure it meets stringent specifications for use as a reference standard and intermediate. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.