Description

n-(p-Toluenesulfonyl)-D,L-Methionine is a protected derivative of the essential amino acid methionine, where the amino group is shielded by a p-toluenesulfonyl (tosyl) group. This chemical modification is crucial for peptide synthesis and organic chemistry, as it prevents unwanted side reactions during the formation of peptide bonds. It is primarily needed by research institutions, pharmaceutical development labs, and fine chemical manufacturers engaged in the production of peptides, bioactive compounds, and advanced intermediates.

Application

• Peptide Synthesis Intermediate: Serves as a key building block in solid-phase and solution-phase peptide synthesis, where the tosyl group acts as a protective group for the methionine residue.
• Pharmaceutical Research & Development: Used in the R&D of novel therapeutic peptides and protein-based drugs that require methionine incorporation.
• Bioconjugation Chemistry: Employed in the synthesis of chemically modified peptides for drug delivery systems, diagnostics, and biochemical probes.
• Fine Chemical Synthesis: Acts as a versatile chiral synthon for the preparation of more complex organic molecules and specialty chemicals.
• Biochemical Research: Utilized in studies of enzyme mechanisms, protein structure-function relationships, and metabolic pathways involving sulfur-containing amino acids.
• Reference Standard: Serves as a high-purity analytical standard for quality control in pharmaceutical and research laboratories.

Basic Information

Product Name	n-(p-Toluenesulfonyl)-D,L-Methionine
CAS No.	4703-33-7
Molecular Formula	C13H19NO4S2
Molecular Weight	317.42 g/mol
Synonyms	N-Tosyl-DL-methionine; N-(4-Methylphenyl)sulfonyl-DL-methionine; DL-Methionine N-tosyl derivative; Tosylmethionine; Methionine tosylate; N-p-Toluenesulfonylmethionine; N-(Tosyl)methionine; 2-Amino-4-(methylthio)butanoic acid N-(4-methylphenyl)sulfonyl derivative
EINECS	Contact for details

Quality Control

Our n-(p-Toluenesulfonyl)-D,L-Methionine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and synthesis applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.