Description

Butyrylthiocholine CAS NO 4555-00-4 is a high-purity biochemical reagent primarily used as a specific substrate for the enzyme butyrylcholinesterase (BChE). This compound is critical for research and diagnostic applications where precise enzymatic activity measurement is required. It is essential for pharmaceutical R&D, clinical diagnostics, and neuroscience studies investigating cholinergic system function and related disorders.

Application

• Clinical Diagnostics: Key substrate in colorimetric and spectrophotometric assays for measuring plasma butyrylcholinesterase (pseudocholinesterase) activity, used in liver function tests and to assess exposure to organophosphate pesticides or nerve agents.
• Pharmaceutical Research: Used in high-throughput screening (HTS) to identify and characterize potential inhibitors or activators of butyrylcholinesterase for drug discovery targeting Alzheimer's disease, myasthenia gravis, and other conditions.
• Toxicology & Environmental Monitoring: Employed in assays to detect and quantify organophosphate and carbamate pesticide exposure in human and animal blood samples, as these compounds inhibit BChE activity.
• Neuroscience Studies: Fundamental tool for studying the role of the cholinergic system, differentiating between acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities in brain tissue and other biological samples.
• Biochemical Reagent Manufacturing: Serves as a raw material for producing diagnostic kits and standardized reagent solutions used in clinical and research laboratories worldwide.
• Quality Control in Anesthesia: Used to assess pseudocholinesterase levels in patients prior to administration of succinylcholine, a muscle relaxant metabolized by BChE, to identify individuals with genetic deficiencies.

Basic Information

Product Name	Butyrylthiocholine
CAS No.	4555-00-4
Molecular Formula	C9H20NO2S+
Molecular Weight	206.33 g/mol (as cation)
Synonyms	Butyrylthiocholine Iodide; S-Butyrylthiocholine; BTC; Butyrylthiocholine cation; 2-Butanoylthioethyl(trimethyl)azanium; (2-Mercaptoethyl)trimethylammonium butyrate ester; Butyrylthiocholine ion; Pseudocholinesterase substrate
EINECS	Contact for details

Quality Control

Our Butyrylthiocholine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and assay, IR for identification, and tests for residual solvents and moisture content, to ensure it meets the high standards required for sensitive biochemical and diagnostic applications. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Melting Point	Contact for details
Heavy Metals	≤ 20 ppm
Solubility	Freely soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.