Description

6Alpha-Fluoro-11Beta,21-Dihydroxy-16Alpha,17-(Isopropylidenedioxy)Pregna-1,4-Diene-3,20-Dione 21-Acetate is a high-purity synthetic corticosteroid intermediate, specifically a fluorinated derivative of prednisolone. This compound is valued for its critical role in the synthesis of advanced anti-inflammatory and immunosuppressive pharmaceutical agents. It is primarily required by pharmaceutical R&D laboratories and active pharmaceutical ingredient (API) manufacturers engaged in the production of potent topical and systemic corticosteroids.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated corticosteroid APIs such as Flunisolide and related analogs.
• Anti-inflammatory Drug Research: Used in preclinical and clinical research for developing new steroidal anti-inflammatory medications.
• Immunosuppressant Synthesis: Serves as a precursor in the manufacture of drugs that modulate the immune system.
• Reference Standard: Employed as an analytical reference standard in quality control laboratories for method development and validation.
• Process Chemistry: Utilized in scale-up and process optimization studies within pharmaceutical development.
• Academic Research: Used in university and institutional research exploring steroid chemistry and pharmacology.

Basic Information

Product Name	6Alpha-Fluoro-11Beta,21-Dihydroxy-16Alpha,17-(Isopropylidenedioxy)Pregna-1,4-Diene-3,20-Dione 21-Acetate
CAS No.	4533-89-5
Molecular Formula	C₂₆H₃₃FO₇
Molecular Weight	476.54 g/mol
Synonyms	6α-Fluoro-11β,21-dihydroxy-16α,17-(isopropylidenedioxy)pregna-1,4-diene-3,20-dione 21-acetate; 6α-Fluoroprednisolone 16α,17α-acetonide 21-acetate; Flunisolide Acetate Intermediate; 6α-Fluoro-δ¹-hydrocortisone 16α,17α-acetonide 21-acetate; 6-Fluoro-11β,17α,21-trihydroxy-16α,17α-isopropylidenedioxypregna-1,4-diene-3,20-dione 21-acetate; NSC 122023; 6α-Fluoro-11β,21-dihydroxy-16α,17α-(isopropylidenedioxy)-1,4-pregnadiene-3,20-dione 21-acetate
EINECS	Contact for details

Quality Control

Our 6Alpha-Fluoro-11Beta,21-Dihydroxy-16Alpha,17-(Isopropylidenedioxy)Pregna-1,4-Diene-3,20-Dione 21-Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing specifications such as assay, related substances, and residual solvents are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Impurity	≤0.5%
Loss on Drying	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.