Description

Pth-L-Proline is a protected derivative of the amino acid L-proline, where the amine group is shielded by a phthaloyl (Pth) group. This modification is critical for enabling selective peptide synthesis and other organic transformations where the primary amine functionality must be temporarily masked. It serves as a key chiral building block and intermediate in the research and production of pharmaceuticals, bioactive peptides, and complex organic molecules. This high-purity compound is essential for chemists and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require reliable, high-quality intermediates for advanced synthetic applications.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system and cardiovascular diseases.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate proline residues while preventing unwanted side reactions at the amine site.
• Asymmetric Catalysis: Serves as a precursor for ligands and organocatalysts used in enantioselective synthesis to create chiral molecules with high optical purity.
• Biochemical Research: Employed in proteomics and enzymology studies to investigate enzyme specificity and to design peptide-based inhibitors or probes.
• Fine Chemical Production: An important intermediate for manufacturing specialty chemicals, agrochemicals, and advanced materials that require specific stereochemistry.
• Academic & R&D Laboratories: A standard reagent for methodological development in organic chemistry and for training purposes in advanced synthetic techniques.

Basic Information

Product Name	Pth-L-Proline
CAS No.	4333-21-5
Molecular Formula	C₁₃H₁₁NO₄
Molecular Weight	245.23 g/mol
Synonyms	N-Phthaloyl-L-proline; (S)-1-(1,3-Dioxoisoindolin-2-yl)pyrrolidine-2-carboxylic acid; L-Proline, N-phthaloyl-; Phthaloylproline; 2-Pyrrolidinecarboxylic acid, 1-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-, (S)-; N-(Phthaloyl)-L-proline; Phth-Pro-OH
EINECS	Contact for details

Quality Control

Our Pth-L-Proline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the stringent requirements for pharmaceutical and research applications. We provide full traceability and detailed Certificates of Analysis (COA) upon request, confirming identity, assay, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting our clients' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is light-sensitive (store away from light). Keep the container tightly sealed to protect from moisture absorption. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.