Description

(+)-Chelidonine Hydrochloride CAS NO 4312-31-6 is the hydrochloride salt of a key benzylisoquinoline alkaloid derived from *Chelidonium majus* (greater celandine). This high-purity reference standard is critical for ensuring analytical accuracy and reproducibility in research and development. It is primarily utilized by pharmaceutical researchers, analytical laboratories, and manufacturers of botanical extracts for method validation, quality control, and pharmacological studies.

Application

• Pharmaceutical Reference Standard: For the identification, assay, and impurity profiling of chelidonine and related alkaloids in drug substances and finished products.
• Biochemical Research: As a potent tool in studies investigating acetylcholinesterase (AChE) inhibition, apoptosis induction, and anti-inflammatory mechanisms.
• Analytical Chemistry: Serves as a primary standard for calibrating HPLC, LC-MS, and TLC systems in quantitative and qualitative analysis of herbal preparations.
• Natural Product Isolation & Synthesis: Used as a benchmark compound for the purification, characterization, and semi-synthetic modification of natural alkaloids.
• Quality Control for Botanical Extracts: Essential for standardizing and certifying the potency and purity of celandine-based dietary supplements and traditional medicines.

Basic Information

Product Name	(+)-Chelidonine Hydrochloride
CAS No.	4312-31-6
Molecular Formula	C20H19NO5·HCl
Molecular Weight	389.83 g/mol
Synonyms	(+)-Chelidonine HCl; Chelidonine hydrochloride; L-Chelidonine hydrochloride; (13aS)-5,8,13,13a-Tetrahydro-3,10-dimethoxy-9-methyl-6H-benzol[g]-1,3-benzodioxolo[5,6-a]quinolizin-6-ol hydrochloride; α-Chelidonine hydrochloride; S-Chelidonine hydrochloride; Stylophorin hydrochloride
EINECS	Contact for details

Quality Control

Our (+)-Chelidonine Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets stringent standards suitable for research and analytical applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.