Description

5,6,7,8-Tetrahydropteroic Acid is a key pterin derivative and a vital biochemical intermediate in the synthesis of folate cofactors. This compound matters significantly for research and development in pharmaceutical chemistry and enzymology, serving as a crucial precursor. It is primarily needed by manufacturers and research institutions focused on developing novel antibiotics, antifolates, and studying folate biosynthesis pathways.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of dihydrofolic acid and other folate analogs for antibiotic and chemotherapeutic agent development.
• Biochemical Research: Used as a standard or substrate in enzymatic studies of dihydropteroate synthase (DHPS), a target for sulfonamide antibiotics.
• Antifolate Drug Development: Serves as a building block for creating novel inhibitors targeting folate metabolism in pathogens and cancer cells.
• Microbiology & Nutrition Studies: Employed in research to understand microbial folate biosynthesis and requirements.
• Reference Standard: Utilized as a high-purity analytical standard in quality control laboratories for HPLC or LC-MS methods.

Basic Information

Product Name	5,6,7,8-Tetrahydropteroic Acid
CAS No.	4299-32-5
Molecular Formula	C14H13N5O4
Molecular Weight	315.29 g/mol
Synonyms	5,6,7,8-Tetrahydro-2-amino-4-hydroxy-6-(pteridin-6-ylmethyl)aminobenzoic acid; 2-Amino-4-hydroxy-6-[(1,2,3,4-tetrahydro-2,4-dioxopteridin-6-yl)methyl]amino]benzoic acid; Tetrahydropteroate; THPA; NSC 52907; Pteroic acid, 5,6,7,8-tetrahydro-
EINECS	Contact for details

Quality Control

Our 5,6,7,8-Tetrahydropteroic Acid is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.