Description

(2S)-2-[[4-[(2,4-Diamino-5,6,7,8-Tetrahydropteridin-6-Yl)Methyl-Methyl -Amino]Benzoyl]Amino]Pentanedioic Acid is a high-purity biochemical intermediate of significant importance in advanced pharmaceutical synthesis. This compound matters as a critical building block for the development of folate analogs and related therapeutic agents, requiring stringent quality control for reliable research and manufacturing outcomes. It is primarily needed by R&D laboratories and production facilities in the pharmaceutical and biotechnology sectors focused on metabolic pathway research and novel drug development.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of specialized folate antagonists and related chemotherapeutic agents.
• Biochemical Research: Used as a reference standard or substrate in enzymatic studies involving folate-dependent metabolic pathways.
• Antifolate Drug Development: A crucial starting material for research into novel dihydrofolate reductase (DHFR) inhibitors.
• Academic & Institutional Research: Employed in universities and research institutes for studying vitamin metabolism and one-carbon transfer reactions.
• Contract Manufacturing (CMO): Supplied to contract development and manufacturing organizations (CDMOs) for cGMP production of active pharmaceutical ingredients (APIs).
• Diagnostic Reagent Formulation: Potential use in the development of diagnostic kits and assays that monitor folate levels or related enzymatic activity.

Basic Information

Product Name	(2S)-2-[[4-[(2,4-Diamino-5,6,7,8-Tetrahydropteridin-6-Yl)Methyl-Methyl -Amino]Benzoyl]Amino]Pentanedioic Acid
CAS No.	4299-28-9
Molecular Formula	C20H26N8O5
Molecular Weight	458.47 g/mol
Synonyms	N-[4-[(2,4-Diamino-5,6,7,8-tetrahydro-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid; L-Glutamic acid, N-[4-[[(2,4-diamino-5,6,7,8-tetrahydro-6-pteridinyl)methyl]methylamino]benzoyl]-; 5,6,7,8-Tetrahydrohomofolic acid; Tetrahydrohomofolate; NSC 139490; Aminopterin analog; Folate analog intermediate
EINECS	Contact for details

Quality Control

Our (2S)-2-[[4-[(2,4-Diamino-5,6,7,8-Tetrahydropteridin-6-Yl)Methyl-Methyl -Amino]Benzoyl]Amino]Pentanedioic Acid is manufactured under a quality management system and undergoes rigorous analytical testing to ensure batch-to-batch consistency and compliance with customer specifications. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles, typically determined by HPLC, NMR, and mass spectrometry. For pharmaceutical applications, production can be aligned with cGMP guidelines upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.