Description

(S)-(+)-1,2-Propanediol CAS NO 4254-15-3 is the high-purity enantiomer of propylene glycol, characterized by its specific (S)-(+) stereochemistry. This chiral building block is essential for applications requiring precise molecular orientation, offering superior performance over racemic mixtures. It is a critical intermediate for pharmaceutical synthesis, agrochemicals, and advanced materials where stereoselectivity dictates functionality and efficacy.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in antiviral, cardiovascular, and central nervous system drugs.
• Agrochemical Synthesis: Used in the production of enantiomerically pure herbicides, fungicides, and pesticides for enhanced biological activity and environmental profile.
• Asymmetric Catalysis & Ligand Synthesis: Serves as a precursor for chiral ligands and catalysts used in stereoselective organic transformations.
• High-Performance Polymers & Resins: Incorporated into specialty polyesters and resins to impart specific optical or mechanical properties.
• Flavor & Fragrance Industry: Employed in the synthesis of chiral aroma chemicals and flavoring agents.
• Electrolyte Solvent for Lithium-ion Batteries: Used in advanced electrolyte formulations for improved battery performance and stability.

Basic Information

Product Name	(S)-(+)-1,2-Propanediol
CAS No.	4254-15-3
Molecular Formula	C3H8O2
Molecular Weight	76.09 g/mol
Synonyms	(S)-Propylene Glycol; (S)-(+)-Propylene Glycol; (S)-1,2-Dihydroxypropane; (S)-1,2-Propanediol; (S)-Methyl ethylene glycol; L-Propylene Glycol; (2S)-Propane-1,2-diol; (S)-(+)-1,2-Propylene Glycol
EINECS	224-208-8

Quality Control

Our (S)-(+)-1,2-Propanediol is manufactured under strict quality management systems. Each batch is tested to ensure high chemical and enantiomeric purity, meeting the stringent requirements for chiral intermediates. We provide comprehensive Certificates of Analysis (COA) detailing specifications for assay, enantiomeric excess (e.e.), and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed to prevent absorption of atmospheric moisture, which can affect quality.

Specification

Item	Specification
Appearance	Colorless clear liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Enantiomeric Excess (e.e.) (Chiral GC/HPLC)	≥ 99.0%
Specific Rotation [α]D20	+15.0° to +16.0° (c=1, H2O)
Water Content (KF)	≤ 0.5%
Refractive Index nD20	1.431 - 1.433
Density (20°C)	1.035 - 1.040 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.