Description

1,2-Dioleoyl-Sn-Glycero-3-Phosphocholine is a high-purity, synthetic phospholipid belonging to the phosphatidylcholine class. This compound is a critical building block for creating liposomes and lipid nanoparticles, valued for its role in enhancing drug delivery and membrane stability. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced material science sectors developing next-generation therapeutics and delivery systems.

Application

• Liposome & Lipid Nanoparticle (LNP) Formulation: A primary structural component for creating stable, uniform vesicles for drug encapsulation and delivery.
• mRNA Vaccine & Gene Therapy Delivery Systems: Used in the lipid bilayer of LNPs to protect and deliver nucleic acids into target cells.
• Model Membrane Studies: Employed in biophysical research to create synthetic lipid bilayers for studying membrane properties and protein-lipid interactions.
• Cosmetic & Dermal Delivery: Incorporated into nano-carriers for the sustained and targeted release of active ingredients in skincare products.
• Diagnostic Agent Carrier: Serves as a vehicle for contrast agents or dyes in imaging and diagnostic applications.
• Cell Culture & Transfection Reagents: A key ingredient in formulations designed to introduce foreign nucleic acids into cultured cells.

Basic Information

Product Name	1,2-Dioleoyl-Sn-Glycero-3-Phosphocholine
CAS No.	4235-95-4
Molecular Formula	C44H84NO8P
Molecular Weight	786.11 g/mol
Synonyms	DOPC; 1,2-Dioleoylphosphatidylcholine; 1,2-Di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine; (2R)-2,3-Bis[[(Z)-octadec-9-enoyl]oxy]propyl 2-(trimethylazaniumyl)ethyl phosphate; Dioleoylphosphatidylcholine; PC(18:1/18:1); Phosphatidylcholine, 1,2-dioleoyl-
EINECS	224-200-4

Quality Control

Our 1,2-Dioleoyl-Sn-Glycero-3-Phosphocholine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical and research applications. A Certificate of Analysis (COA) detailing specific results for purity, residual solvents, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and hydrolysis. The material is hygroscopic and must be handled in a dry environment to minimize moisture uptake. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white waxy solid or powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (TLC)	Single spot
Lyso-PC Impurity (HPLC)	≤ 1.0%
Solvent Residues (GC)	Meets ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.