Description

H-Leu-Pna CAS NO 4178-93-2 is a high-purity protected amino acid derivative, specifically L-Leucine p-nitroanilide. This compound serves as a critical synthetic intermediate and biochemical substrate, valued for its role in peptide synthesis and enzymatic research. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require reliable, high-quality building blocks for drug discovery and proteomics applications.

Application

• Peptide Synthesis Intermediate: A key protected building block for the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics.
• Enzymology & Protease Research: Used as a chromogenic substrate for the assay and characterization of various proteolytic enzymes, including leucine aminopeptidases.
• Biochemical Reagent: Employed in research laboratories for studying enzyme kinetics, inhibition, and substrate specificity.
• Pharmaceutical Development: Utilized in the R&D of novel therapeutic agents, particularly in the development of enzyme inhibitors and diagnostic tools.
• Academic Research: A standard reagent in university and institutional labs for biochemical and medicinal chemistry studies.

Basic Information

Product Name	H-Leu-Pna
CAS No.	4178-93-2
Molecular Formula	C12H17N3O3
Molecular Weight	251.28 g/mol
Synonyms	L-Leucine p-nitroanilide; L-Leu-pNA; H-Leu-pNA; Leucine 4-nitroanilide; N-(4-Nitrophenyl)-L-leucinamide; L-Leu-p-Nitroanilide; 4-Nitroanilide of L-leucine; Leucine p-nitroanilide
EINECS	Contact for details

Quality Control

Our H-Leu-Pna is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and synthesis. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, chiral purity, and impurity profiles. Our quality systems are designed to meet the stringent requirements of GMP and ISO standards for fine chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed immediately after use to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.