Description

3,4,5-Trimethoxybenzo-Amidite Hydrocloride is a key chemical intermediate, primarily used in the synthesis of complex organic molecules. Its value lies in its role as a protected phosphoramidite building block, essential for constructing oligonucleotides and other nucleotide analogs in a controlled manner. This compound is critically needed by research institutions and pharmaceutical companies engaged in drug discovery, nucleic acid chemistry, and the development of therapeutic agents.

Application

• Oligonucleotide Synthesis: Serves as a crucial phosphoramidite monomer for the solid-phase synthesis of DNA and RNA sequences.
• Pharmaceutical Intermediates: Used in the research and development of novel antiviral and anticancer drugs that target genetic pathways.
• Probe and Primer Manufacturing: A key raw material for producing labeled probes and primers used in PCR, sequencing, and diagnostic assays.
• Antisense Therapy Development: Employed in the creation of antisense oligonucleotides designed to modulate gene expression.
• Bioconjugation Chemistry: Acts as a linker or functional group for attaching reporter molecules or other moieties to biomolecules.
• Academic and Industrial R&D: Utilized in chemical biology and medicinal chemistry research for exploring nucleotide-based therapeutics.

Basic Information

Product Name	3,4,5-Trimethoxybenzo-Amidite Hydrocloride
CAS No.	4156-59-6
Molecular Formula	C16H27N2O5P • HCl
Molecular Weight	409.84 g/mol (Free base: 373.37 g/mol)
Synonyms	3,4,5-Trimethoxybenzoic Acid N,N-Diisopropyl-2-cyanoethyl Phosphoramidite Hydrochloride; 1H-1,2-Benzodioxole-3-methanol, 6-nitro-α-((3,4,5-trimethoxyphenyl)methyl)-, Carbamate (ester); TMB Phosphoramidite HCl; 3,4,5-Trimethoxybenzamidite Hydrochloride; N,N-Diisopropyl-O-(2-cyanoethyl)-3,4,5-trimethoxybenzoyl Phosphoramidite Hydrochloride; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 3,4,5-Trimethoxybenzo-Amidite Hydrocloride is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to industry best practices, and specifications can be aligned with research or cGMP guidelines as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to maintain stability, especially after opening the primary container. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in acetonitrile, dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.