Description

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine is a high-purity synthetic phospholipid, specifically a phosphatidylethanolamine (PE) with unsaturated oleoyl chains. This compound is a critical building block in advanced lipid-based formulations, valued for its role in creating stable, fusogenic membranes. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and nutraceutical industries developing next-generation delivery systems and biomimetic models.

Application

• Liposome & Nanoparticle Formulation: A key component for creating stable, fusogenic liposomes used in drug and gene delivery systems.
• mRNA Vaccine & Therapeutic Development: Used in lipid nanoparticle (LNP) formulations to encapsulate and protect nucleic acids.
• Cell Membrane Mimetics: Essential for constructing model membranes and vesicles for biophysical research and diagnostic assay development.
• Cosmetic Actives Delivery: Employed in cosmetic formulations to enhance the skin penetration and stability of active ingredients.
• Biochemical Research: Serves as a substrate or structural lipid in enzymatic studies and membrane protein research.
• Diagnostic Reagents: Used in the production of reagents for clinical diagnostics and imaging.

Basic Information

Product Name	1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
CAS No.	4004-05-1
Molecular Formula	C41H78NO8P
Molecular Weight	744.03 g/mol
Synonyms	DOPE; 1,2-Dioleoylphosphatidylethanolamine; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine; (2R)-2,3-Bis[[(Z)-octadec-9-enoyl]oxy]propyl 2-aminoethyl hydrogen phosphate; Dioleoylphosphatidylethanolamine; Phosphatidylethanolamine, dioleoyl; L-α-Phosphatidylethanolamine, dioleoyl; Avanti Number 850725
EINECS	223-663-6

Quality Control

Our 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine is produced under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the exacting standards required for pharmaceutical and life science applications. A comprehensive Certificate of Analysis (COA) detailing purity, residual solvents, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the product to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white waxy solid or clear oil
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines
Peroxide Value	≤ 3.0 meq/kg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.