Description

Guvacine Hydrochloride is a high-purity, pharmacologically active alkaloid derivative. This compound is valued for its role as a selective GABA uptake inhibitor, making it a critical intermediate and reference standard in neuroscience and pharmaceutical research. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of neurological therapeutics and diagnostic agents.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel neuroactive compounds and potential drug candidates.
• Biochemical Research: Used as a selective inhibitor in studies of GABA (γ-aminobutyric acid) neurotransmission, receptor function, and synaptic plasticity.
• Reference Standard: Employed as an analytical standard in HPLC, LC-MS, and NMR for quality control and method validation in pharmaceutical analysis.
• Neuroscience Studies: Applied in *in vitro* and *in vivo* models to investigate conditions related to GABAergic system dysfunction.
• Diagnostic Agent Development: Explored in the research and development of diagnostic tools and imaging agents for neurological disorders.

Basic Information

Product Name	Guvacine Hydrochloride
CAS No.	498-96-4
Molecular Formula	C6H9NO2 • HCl
Molecular Weight	163.60 g/mol
Synonyms	1,2,5,6-Tetrahydro-3-pyridinecarboxylic acid hydrochloride; 3-Carboxy-1,4,5,6-tetrahydropyridine hydrochloride; Guvacine HCl; Norarecoline carboxylic acid hydrochloride; Arecaidine carboxylic acid hydrochloride; 3-Piperidinecarboxylic acid, 1,2,5,6-tetrahydro-, hydrochloride
EINECS	207-879-8

Quality Control

Our Guvacine Hydrochloride is manufactured under a quality management system and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing results from tests including assay, impurity profile, and identification. The product is suitable for research and development applications requiring high-purity standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.