Description

Lumicolchicine CAS NO 490-24-4 is a significant photoisomer of the natural alkaloid colchicine, formed upon exposure to ultraviolet light. This compound is of critical importance in biochemical and pharmacological research for studying tubulin binding mechanisms and cellular processes. It serves as a key reference standard and research tool for scientists in the pharmaceutical, biotechnology, and academic sectors investigating mitosis, cytoskeleton dynamics, and the development of novel therapeutic agents.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quality control and analytical method development of colchicine-based pharmaceuticals.
• Biochemical Research: Essential tool for studying the inhibition of microtubule polymerization and its effects on cell division (mitosis) in cancer research.
• Mechanistic Studies: Employed to investigate the structure-activity relationship (SAR) of colchicine-binding site agents and their photochemical behavior.
• Academic Research: Utilized in university and institutional labs for fundamental studies in cell biology, pharmacology, and organic photochemistry.
• Analytical Method Development: Serves as a critical impurity or degradation product marker in HPLC and LC-MS methods for colchicine assay.

Basic Information

Product Name	Lumicolchicine
CAS No.	490-24-4
Molecular Formula	C22H25NO6
Molecular Weight	399.44 g/mol
Synonyms	β-Lumicolchicine; NSC 406042; Colchicine, photoisomer; (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide; Lumi-colchicine; Colchicine photoproduct
EINECS	207-699-3

Quality Control

Our Lumicolchicine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis to ensure it meets the high standards required for research applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure the container is kept tightly sealed in a desiccated environment away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.