Description

(2R)-2-Hydroxy-2-[(R)-1-Methoxyethyl]-3-Methylbutanoic Acid [(7As)-2,3,5,7A-Tetrahydro-1H-Pyrrolizin-7-Yl]Methyl Ester is a high-purity chiral ester with a complex bicyclic structure, making it a valuable intermediate for advanced organic synthesis. Its defined stereochemistry is critical for applications requiring precise molecular orientation and biological activity. This compound is primarily sought by research institutions and pharmaceutical developers for use in creating novel active pharmaceutical ingredients (APIs) and complex natural product analogs.

Application

• Pharmaceutical Intermediate: A key chiral building block in the research and development of new therapeutic agents, particularly for complex molecule synthesis.
• Asymmetric Synthesis: Utilized as a sophisticated reagent or precursor in stereoselective chemical reactions to construct molecules with specific three-dimensional configurations.
• Natural Product Research: Serves as a synthetic analog or intermediate in the study and total synthesis of complex alkaloids and other natural products.
• Chemical Reference Standard: Used as a high-purity analytical standard for method development, quality control, and regulatory compliance in pharmaceutical analysis.
• Academic & Industrial R&D: Employed in exploratory chemistry for developing new synthetic methodologies and investigating structure-activity relationships (SAR).

Basic Information

Product Name	(2R)-2-Hydroxy-2-[(R)-1-Methoxyethyl]-3-Methylbutanoic Acid [(7As)-2,3,5,7A-Tetrahydro-1H-Pyrrolizin-7-Yl]Methyl Ester
CAS No.	488-00-6
Molecular Formula	C16H27NO4
Molecular Weight	297.39 g/mol
Synonyms	Loline Methyl Ester; Loline alkaloid derivative; (7aS)-7-[[(2R)-2-Hydroxy-2-[(1R)-1-methoxyethyl]-3-methyl-1-oxobutoxy]methyl]hexahydro-1H-pyrrolizine; Methyl (2R,1'R)-2-hydroxy-2-(1-methoxyethyl)-3-methylbutyrate (7aS)-2,3,5,7a-tetrahydro-1H-pyrrolizin-7-ylmethyl ester; 1H-Pyrrolizine-7-methanol, 2,3,5,7a-tetrahydro-, (7aS)-, 2-hydroxy-2-[(1R)-1-methoxyethyl]-3-methylbutanoate
EINECS	Contact for details

Quality Control

Our production of (2R)-2-Hydroxy-2-[(R)-1-Methoxyethyl]-3-Methylbutanoic Acid [(7As)-2,3,5,7A-Tetrahydro-1H-Pyrrolizin-7-Yl]Methyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and development. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥95% by HPLC), and impurity profiles. We operate under a quality management system to meet the exacting standards required for pharmaceutical intermediates and fine chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). For long-term storage, consider holding the material under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Specific Rotation	Contact for details
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.