Description

Porphobilinogen CAS NO 487-90-1 is a key pyrrole intermediate in the biosynthesis of heme, chlorophyll, and vitamin B12. Its high purity and stability are critical for accurate biochemical research and diagnostic applications. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and clinical diagnostics industries, particularly for studying porphyrias and metabolic disorders.

Application

• Biochemical Research: Critical substrate and standard for studying the heme biosynthesis pathway and enzymatic activity of porphobilinogen deaminase (hydroxymethylbilane synthase).
• Clinical Diagnostics: Used as a reference standard in laboratory tests for the diagnosis of acute intermittent porphyria and other hepatic porphyrias.
• Pharmaceutical Development: Serves as a key intermediate in research focused on metabolic disorders and potential therapeutic interventions.
• Enzyme Assays: Essential component in in vitro assays to measure enzyme kinetics and inhibitor screening for relevant biosynthetic enzymes.
• Metabolite Analysis: Used in mass spectrometry and chromatography as a calibration standard for quantitative analysis of porphyrin precursors in biological samples.
• Educational & Reference Material: Supplied to academic and institutional laboratories for teaching and standardized research protocols.

Basic Information

Product Name	Porphobilinogen
CAS No.	487-90-1
Molecular Formula	C10H14N2O4
Molecular Weight	226.23 g/mol
Synonyms	3-[5-(Aminomethyl)-4-(carboxymethyl)-1H-pyrrol-3-yl]propanoic acid; PBG; 1-Amino-4,5-dioxo-4,5-dihydro-1H-pyrrol-2-yl)methyl]amino)methaniminium; 5-Aminolevulinic acid derivative; Porphobilinogen hydrate; Uroporphyrinogen I synthase substrate; HMBS substrate
EINECS	207-668-9

Quality Control

Our Porphobilinogen is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for sensitive research and diagnostic use. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality guidelines suitable for research and diagnostic standard applications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. The product is hygroscopic (moisture-sensitive) and light-sensitive; ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture and light. For long-term storage, consider desiccants and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area %)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Biological Activity	Tested in enzymatic assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.