Description

Fluoroacetyl-Coenzyme A is a specialized biochemical reagent featuring a fluoroacetyl group esterified to coenzyme A. This compound is critical for studying and manipulating metabolic pathways, particularly those involving fatty acid synthesis and degradation, due to its role as a mechanism-based inhibitor. It is primarily utilized by researchers and developers in pharmaceutical discovery, enzymology, and metabolic research to investigate enzyme mechanisms and develop novel therapeutic strategies.

Application

• Enzyme Inhibition Studies: Used as a potent, mechanism-based inhibitor of citrate synthase and other enzymes in the tricarboxylic acid (TCA) cycle.
• Metabolic Pathway Research: Essential for probing fatty acid metabolism, gluconeogenesis, and energy production pathways in vitro.
• Pharmaceutical Development: Serves as a key biochemical tool in drug discovery programs targeting metabolic diseases and cancer.
• Biochemical Assay Standard: Employed as a reference standard in enzymatic assays and for calibrating analytical methods.
• Academic Research: Fundamental reagent for university and institutional research into biochemistry and molecular biology.
• Toxicology Studies: Applied in research on fluoroacetate toxicity and the mechanism of action of related compounds.

Basic Information

Product Name	Fluoroacetyl-Coenzyme A
CAS No.	485-13-2
Molecular Formula	C23H36N7O17P3S
Molecular Weight	855.54 g/mol
Synonyms	Fluoroacetyl-CoA; S-Fluoroacetylcoenzyme A; Coenzyme A, S-fluoroacetyl; Fluoracetyl-Coenzym A; 2-Fluoroacetyl-CoA; Acetyl-CoA, 2-fluoro-; (2R)-2-Fluoro-3-oxo-3-[(3R)-5-({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)-2-hydroxy-3,3-dimethyl-4-oxobutyl]sulfanyl]propyl dihydrogen diphosphate
EINECS	207-618-8

Quality Control

Our Fluoroacetyl-Coenzyme A is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 quality management standards, and our processes are designed to meet the rigorous demands of pharmaceutical and academic research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white powder or lyophilized solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Biological Activity	Inhibits citrate synthase (IC50 provided on COA)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.