Description

Tetrahydroprotoberberine is a key intermediate and reference standard belonging to the protoberberine class of alkaloids. This compound is of significant interest in pharmaceutical research and development due to its structural relationship to bioactive natural products. It serves as a critical building block for the synthesis of more complex alkaloids and is utilized in biochemical and pharmacological studies. Industries involved in fine chemical synthesis, phytochemical analysis, and drug discovery will find this high-purity material essential for their processes.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of various isoquinoline alkaloids with potential therapeutic applications.
• Biochemical Research: Used as a reference standard and probe in studies investigating alkaloid biosynthesis pathways and enzyme mechanisms.
• Natural Product Chemistry: Acts as a model compound for the isolation, identification, and structural elucidation of related protoberberine alkaloids from plant sources.
• Pharmacological Screening: Employed in in vitro and in vivo assays to evaluate biological activities such as antimicrobial, anti-inflammatory, or neurological effects.
• Analytical Standard: Provides a high-purity benchmark for quality control and quantitative analysis (e.g., HPLC, LC-MS) in herbal extract and finished product testing.
• Academic & Institutional Research: Supports fundamental chemical and biological research in universities and government laboratories.

Basic Information

Product Name	Tetrahydroprotoberberine
CAS No.	483-49-8
Molecular Formula	C20H21NO4
Molecular Weight	339.39 g/mol
Synonyms	Canadine; (S)-Canadine; Tetrahydroberberine; 5,6,13,13a-Tetrahydro-8,9-dimethoxy[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinoline; 9,10-Dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinoline; NSC 172925; THPB
EINECS	207-599-6

Quality Control

Our Tetrahydroprotoberberine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (IR, NMR). We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or production specifications. For custom purity grades or specific impurity profiles, please contact our technical team.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.