Description

Corynanthine CAS NO 483-10-3 is a natural indole alkaloid derived from plants of the *Corynanthe* genus, known for its specific pharmacological profile as a selective α2-adrenergic receptor antagonist. This compound is of significant interest for its role in neurological and cardiovascular research, serving as a critical reference standard and a key intermediate in the development of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers engaged in neuroscience, receptor studies, and alkaloid chemistry.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis of alkaloid-based drugs and botanical extracts in quality control laboratories.
• Neurological Research: Employed as a selective α2-adrenergic receptor antagonist to study receptor function, signal transduction pathways, and the mechanisms of related neurological disorders.
• Cardiovascular Research: Investigated for its effects on blood pressure regulation and vascular tone due to its interaction with adrenergic receptors.
• Fine Chemical Synthesis: Serves as a sophisticated chiral building block or intermediate in the multi-step synthesis of complex natural products and potential drug candidates.
• Botanical & Natural Product Analysis: Acts as a marker compound for the identification and standardization of herbal preparations containing *Corynanthe* or related plant species.
• Biochemical Assay Development: Utilized in high-throughput screening (HTS) assays to discover and evaluate new compounds targeting α2-adrenergic receptors.

Basic Information

Product Name	Corynanthine
CAS No.	483-10-3
Molecular Formula	C21H26N2O3
Molecular Weight	354.45 g/mol
Synonyms	Corynanthine; Corynanthidine; α-Yohimbine; Raubasine; 17α-Hydroxyyohimban-16α-carboxylic acid methyl ester; (16α,17α)-17-Hydroxyyohimban-16-carboxylic acid methyl ester; 3-Epi-α-yohimbine
EINECS	207-590-8

Quality Control

Our Corynanthine is produced and tested under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines, and specifications can be tailored to meet specific project requirements, including those for use as a reference standard.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.