Description

(20α)-17α-Methoxy-18β-[(3,4,5-Trimethoxybenzoyl)Oxy]Yohimban-16β-Carboxylic Acid Methyl Ester is a complex, semi-synthetic indole alkaloid derivative of significant interest in advanced pharmaceutical research and development. This compound matters as a key intermediate or reference standard for the synthesis and study of novel therapeutic agents targeting the central nervous system. Pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in neuropharmacology and medicinal chemistry are the primary users of this high-purity chemical.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of complex alkaloid-based active pharmaceutical ingredients (APIs).
• Reference Standard: Used for analytical method development, validation, and quality control (QC) in pharmaceutical manufacturing, ensuring batch-to-batch consistency.
• Medicinal Chemistry Research: A valuable scaffold for structure-activity relationship (SAR) studies aimed at discovering new drugs with potential neurological or cardiovascular activity.
• Biochemical Research: Employed in in vitro studies to investigate interactions with specific receptors or enzymes within the indole alkaloid pathway.
• Process Development: Used in scaling up and optimizing synthetic routes for the production of related yohimbine analogs in a GMP environment.

Basic Information

Product Name	(20α)-17α-Methoxy-18β-[(3,4,5-Trimethoxybenzoyl)Oxy]Yohimban-16β-Carboxylic Acid Methyl Ester
CAS No.	482-87-1
Molecular Formula	C31H38N2O8
Molecular Weight	566.65 g/mol
Synonyms	Methyl (20α)-17α-methoxy-18β-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16β-carboxylate; 18β-Hydroxyyohimban-16β-carboxylic acid methyl ester 3,4,5-trimethoxybenzoate (ester) 17α-methyl ether; Rescinnamine Impurity; Reserpine Related Compound; Yohimban-16β-carboxylic acid, 18-[(3,4,5-trimethoxybenzoyl)oxy]-, methyl ester, (16β,17α,18β,20α)-; Trimethoxybenzoyl Yohimbine Methyl Ester
EINECS	Contact for details

Quality Control

Our (20α)-17α-Methoxy-18β-[(3,4,5-Trimethoxybenzoyl)Oxy]Yohimban-16β-Carboxylic Acid Methyl Ester is produced and tested under a strict quality management system. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data (HPLC) are provided to support your regulatory and quality documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.