Description

(-)-Isoreserpine CAS NO 482-85-9 is a high-purity, stereochemically defined alkaloid compound derived from *Rauwolfia serpentina*. This specific enantiomer is of significant interest for its precise biological activity and serves as a critical reference standard and building block in advanced pharmaceutical research. It is essential for scientists and manufacturers engaged in the development and quality control of cardiovascular and neurological therapeutics. Our supply ensures consistent quality and reliable availability for demanding R&D and production applications.

Application

• Pharmaceutical Reference Standard: Primary use as a certified standard for the identification, assay, and impurity profiling of reserpine and related alkaloids in pharmacopeial testing (e.g., USP, EP).
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key chiral precursor in the synthetic or semi-synthetic production of antihypertensive and antipsychotic medications.
• Biochemical Research: Used in neuroscience and cardiovascular studies to investigate mechanisms of action related to vesicular monoamine transporter 2 (VMAT2) and catecholamine depletion.
• Analytical Chemistry: Employed as a critical component in method development and validation for HPLC, LC-MS, and other chromatographic analyses in quality control laboratories.
• Process Development & Validation: Utilized in scaling up synthetic pathways and validating manufacturing processes for regulatory compliance (FDA, EMA).

Basic Information

Product Name	(-)-Isoreserpine
CAS No.	482-85-9
Molecular Formula	C33H40N2O9
Molecular Weight	608.68 g/mol
Synonyms	Isoreserpine; (3β,16β,17α,18β,20α)-11,17-Dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic acid methyl ester; Reserpine isomer; 17-Epireserpine; NSC 336579; Reserpine Impurity; Yohimban-16-carboxylic acid derivative
EINECS	207-598-5

Quality Control

Every batch of (-)-Isoreserpine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high standards required for pharmaceutical development. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting identity, purity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods. Our quality commitment supports compliance with cGMP and relevant ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. For long-term storage, consider storing under inert atmosphere at 2-8°C to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0% (anhydrous basis)
Specific Rotation [α]20/D	-90° to -100° (c=1 in CHCl3)
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.