Description

6-Amino-9-[3-Hydroxy-5-[(Hydroxy-Sulfooxy-Phosphoryl)Oxymethyl]-4-Phosphonooxy-Oxolan-2-Yl]-Purine is a high-purity nucleotide derivative, also known as adenosine 3',5'-cyclic monophosphate (cyclic AMP or cAMP), a critical secondary messenger in biological signal transduction. This compound is essential for research and development in biochemistry and molecular biology, enabling the study of intracellular signaling pathways, enzyme regulation, and gene expression. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and manufacturers of diagnostic reagents and biochemical standards.

Application

• Biochemical Research: As a key secondary messenger for studying cell signaling, protein kinase A (PKA) activation, and metabolic regulation.
• Pharmaceutical Development: Used in drug discovery programs targeting G-protein-coupled receptors (GPCRs) and pathways involving cyclic nucleotide signaling.
• Diagnostic Reagent Manufacturing: Serves as a critical component or standard in enzyme immunoassays (EIAs) and other diagnostic kits for research purposes.
• Cell Culture & Physiology Studies: Applied in vitro to investigate the effects of cAMP on cell growth, differentiation, and hormonal responses.
• Enzyme Substrate: Used as a substrate for phosphodiesterases (PDEs) in enzymatic activity assays and inhibitor screening.
• Reference Standard: Acts a high-purity analytical standard for quality control in the production of related biochemicals.

Basic Information

Product Name	6-Amino-9-[3-Hydroxy-5-[(Hydroxy-Sulfooxy-Phosphoryl)Oxymethyl]-4-Phosphonooxy-Oxolan-2-Yl]-Purine
CAS No.	482-67-7
Molecular Formula	C10H12N5O6P
Molecular Weight	329.21 g/mol
Synonyms	Adenosine 3',5'-cyclic monophosphate; Cyclic AMP; cAMP; Adenosine cyclic 3',5'-(hydrogen phosphate); 3',5'-Cyclic adenylic acid; 3',5'-Cyclic adenosine monophosphate; Cyclic adenosine 3',5'-monophosphate; NSC 94017
EINECS	207-604-5

Quality Control

Our 6-Amino-9-[3-Hydroxy-5-[(Hydroxy-Sulfooxy-Phosphoryl)Oxymethyl]-4-Phosphonooxy-Oxolan-2-Yl]-Purine (cAMP) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccant and under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Biological Activity	Tested in standard PKA activation assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.