Description

Estradiol-3-Sulfate is a sulfated metabolite of the primary female sex hormone, estradiol. This compound is of significant importance as a stable, water-soluble conjugate used in research and diagnostic applications. It is primarily required by pharmaceutical R&D laboratories, clinical diagnostics manufacturers, and academic institutions studying steroid metabolism and hormone-related pathways.

Application

• Biochemical Research: Used as a critical reference standard and reagent in studies of estrogen metabolism, sulfotransferase enzyme activity, and hormone conjugation pathways.
• Diagnostic Kit Manufacturing: Serves as a calibrator or component in immunoassay kits for the quantitative measurement of estrogen levels in clinical and research settings.
• Pharmaceutical Development: Employed in the research and development of hormone therapies and in studies investigating the pharmacokinetics of estrogen derivatives.
• Metabolite Identification: Acts as a definitive standard in mass spectrometry (LC-MS/MS) for the identification and quantification of estradiol sulfate in biological matrices.
• Endocrinology Studies: Utilized in vitro and in vivo research to understand the role of sulfated hormones in various physiological and pathological processes.

Basic Information

Product Name	Estradiol-3-Sulfate
CAS No.	481-96-9
Molecular Formula	C18H22O5S
Molecular Weight	350.43 g/mol
Synonyms	Estrone 3-Sulfate; Estradiol 3-Sulfate; 17β-Estradiol 3-Sulfate; E1S; Estradiol Sulfate; Estra-1,3,5(10)-triene-3,17β-diol 3-sulfate; 3-Hydroxyestra-1,3,5(10)-trien-17-one 3-sulfate
EINECS	207-576-6

Quality Control

Our Estradiol-3-Sulfate is manufactured and tested under a strict quality management system. Each batch is analyzed to ensure high chemical purity and identity, meeting the exacting standards required for research and diagnostic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and identification tests is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solubility	Soluble in water, methanol; slightly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.