Description

Retronecine is a pyrrolizidine alkaloid (PA) and a key structural component and metabolic precursor of many hepatotoxic and pneumotoxic natural compounds. Its significance lies in its role as a critical intermediate and reference standard for toxicological research and analytical method development. This high-purity compound is essential for researchers and quality control laboratories in the pharmaceutical, phytochemical, and food safety industries who require reliable materials for studying pyrrolizidine alkaloid toxicity, metabolism, and detection.

Application

• Phytochemical Reference Standard: Serves as a primary chemical standard for the identification and quantification of pyrrolizidine alkaloids in complex plant extracts and herbal products.
• Toxicology Research: Used as a key intermediate in studies investigating the metabolic activation, hepatotoxicity, and genotoxicity mechanisms of pyrrolizidine alkaloids.
• Analytical Method Development: Critical for developing and validating sensitive analytical methods, such as HPLC-MS/MS, for the detection of PAs in food, feed, and botanical ingredients.
• Pharmaceutical Impurity Profiling: Employed in the safety assessment of herbal medicines to identify and control potentially harmful pyrrolizidine alkaloid impurities.
• Biochemical Research: Utilized as a substrate or inhibitor in enzymatic studies related to PA biosynthesis and detoxification pathways.
• Food Safety Testing: Acts as a calibration standard in laboratories monitoring PA contamination in honey, teas, spices, and dietary supplements to ensure consumer safety.

Basic Information

Product Name	Retronecine
CAS No.	480-85-3
Molecular Formula	C8H13NO2
Molecular Weight	155.19 g/mol
Synonyms	Retronecan-12-ol; 1,2,5,6-Tetrahydro-2,5-dihydroxymethyl-3H-pyrrolizine-3,7-dione; 1-Hydroxymethyl-7-hydroxy-2,3,5,6-tetrahydro-1H-pyrrolizine; (1R,7R)-1,2,5,6-Tetrahydro-2,5-dihydroxymethyl-3H-pyrrolizine-3,7-dione; Pyrrolizidine alkaloid necine base
EINECS	207-553-5

Quality Control

Our Retronecine is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods (IR, NMR) and purity assessment by chromatographic techniques (HPLC). A detailed Certificate of Analysis (COA) documenting the purity, assay, and related substances is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.