Description

Integerrimine is a naturally occurring pyrrolizidine alkaloid (PA) of significant interest in research and development. Its unique chemical structure makes it a valuable reference standard and a key compound for studying the biological activity and toxicology of pyrrolizidine alkaloids. This high-purity compound is essential for researchers and quality control laboratories in the pharmaceutical, phytochemical, and analytical chemistry sectors who require reliable, well-characterized materials for method development and validation.

Application

• Phytochemical Reference Standard: Used as a certified reference material (CRM) for the identification and quantification of pyrrolizidine alkaloids in complex botanical extracts, herbal products, and dietary supplements.
• Toxicological Research: Serves as a model compound in studies investigating the hepatotoxic and genotoxic mechanisms of pyrrolizidine alkaloids, crucial for safety assessments.
• Pharmaceutical Impurity Profiling: Employed in analytical method development (e.g., HPLC, LC-MS) to detect and control potentially harmful PA impurities in drug substances derived from natural sources.
• Food and Feed Safety Analysis: A critical analytical standard for monitoring and ensuring compliance with regulatory limits on pyrrolizidine alkaloid contamination in honey, teas, spices, and animal feed.
• Metabolite Studies: Used in research to identify and characterize the metabolic pathways and products of pyrrolizidine alkaloids in biological systems.

Basic Information

Item	Detail
Product Name	Integerrimine
CAS No.	480-79-5
Molecular Formula	C18H25NO5
Molecular Weight	335.40 g/mol
Synonyms	Integerrimine; (-)-Integerrimine; Integerrine; 12,13-Dihydro-7-hydroxy-8,20-epoxy-13-(hydroxymethyl)-14,15-dimethyl-2,5,9,16-tetraazapentacyclo[10.6.1.01,9.02,6.015,19]nonadeca-12,14,17-triene-3,10-dione; Integerrimine (pyrrolizidine alkaloid); (1R,7aR,13aR,13bS)-1,2,3,5,6,7,7a,13a,13b,14-Decahydro-1,13b-dihydroxy-7a-(hydroxymethyl)-4,8-dimethyl-10,12-dioxo-11,15-dioxa-4-azatetracyclo[7.6.1.02,7.013,17]hexadeca-5,15-dien-14-yl acetate
EINECS	Contact for details

Quality Control

Our Integerrimine is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, typically meeting standards suitable for analytical and research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation via spectroscopic methods, and impurity profiles. We support compliance with relevant pharmacopeial and industry guidelines for reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.