Description

Retrorsine is a pyrrolizidine alkaloid (PA) of significant interest in biochemical and pharmaceutical research. This compound is valued for its role as a reference standard in the study of hepatotoxicity and as a key marker for the quality control of herbal products and botanicals. It is primarily utilized by research institutions, analytical laboratories, and manufacturers in the phytopharmaceutical and nutraceutical sectors who require high-purity chemical standards for method development, validation, and toxicological assessment.

Application

• Phytochemical Reference Standard: Serves as a certified primary standard for the qualitative and quantitative analysis of pyrrolizidine alkaloids in complex matrices.
• Toxicological Research: Used in in vitro and in vivo studies to investigate the mechanisms of hepatotoxicity, genotoxicity, and metabolic activation associated with pyrrolizidine alkaloids.
• Herbal Medicine Quality Control: A critical marker compound for the detection and quantification of toxic PAs in herbal ingredients, teas, supplements, and finished products to ensure consumer safety.
• Method Development & Validation: Essential for developing and validating analytical methods such as HPLC, LC-MS/MS, and GC-MS for PA profiling in compliance with regulatory guidelines.
• Biochemical Pathway Studies: Employed to study biosynthetic pathways in plants and the metabolic pathways (e.g., cytochrome P450 metabolism) in biological systems.
• Pharmaceutical Impurity Profiling: Used to identify and control potentially genotoxic impurities (PGIs) in drug substances derived from botanical sources.

Basic Information

Product Name	Retrorsine
CAS No.	480-54-6
Molecular Formula	C18H25NO6
Molecular Weight	351.40 g/mol
Synonyms	12,18-Dihydroxysenecionan-11,16-dione; (13α,14α)-13,19-Didehydro-12,18-dihydroxysenecionan-11,16-dione; Retrorecine 12-angelate; Retrorsine N-oxide (impurity); Senecionine analog; PA standard; Pyrrolizidine alkaloid reference material
EINECS	207-555-5

Quality Control

Our Retrorsine is produced under a strict quality management system to ensure batch-to-batch consistency and high purity suitable for research and analytical applications. Each lot is characterized using advanced spectroscopic and chromatographic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profile is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C to maximize stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.