Description

Filipin Iii is a polyene macrolide antibiotic complex, with the specific component Filipin III identified by CAS 480-49-9. This compound is valued for its potent antifungal activity and its specific interaction with membrane sterols, particularly cholesterol. It serves as a critical research tool in biochemistry and cell biology for studying membrane structure, lipid rafts, and sterol function. Key users include pharmaceutical R&D laboratories, academic research institutions, and manufacturers of diagnostic reagents.

Application

• Biochemical Research: As a selective probe for visualizing and disrupting cholesterol-rich membrane domains (lipid rafts) in cellular studies.
• Antifungal Agent Studies: Used in research to investigate the mechanism of action of polyene antibiotics against fungal pathogens.
• Membrane Biophysics: Employed to study the physicochemical properties of biomembranes and sterol-lipid interactions.
• Pharmaceutical Development: Serves as a reference standard or lead compound in the discovery of novel antifungal therapeutics.
• Diagnostic Reagent Component: Potential use in assay kits designed to detect or quantify cholesterol in biological samples.

Basic Information

Product Name	Filipin Iii
CAS No.	480-49-9
Molecular Formula	C35H58O11
Molecular Weight	654.83 g/mol
Synonyms	Filipin III; Filipin 3; NSC 3364; Antibiotic U 5956; 28,29-Didehydrofilipin I; 5,7,9,11,13,15,17,19,21,23,25,27-Dodecaene-1,3-diol, 33-[(2R,6S)-6-methyl-7-oxo-2,6-epoxyoxepan-2-yl]-6,9,12,15,18,21,24,27,30-nonahydroxy-10,13,16,19,22,25,28-heptamethyl-33-(1-methyl-2-oxobutyl)-, (1S,3S,5E,7E,9E,11E,13E,15E,17E,19E,21E,23E,25E,27E,33R)-
EINECS	207-549-5

Quality Control

Our Filipin III is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot is characterized using advanced analytical techniques, including HPLC for purity assessment and spectroscopic methods for structural confirmation. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.