Description

Indirubin is a naturally occurring red isomer of indigo, a bioactive compound with significant pharmacological interest. Its unique chemical structure underpins its role as a potent inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase-3β (GSK-3β), making it a valuable research chemical. This product is essential for researchers and developers in the pharmaceutical, biotechnology, and life science sectors exploring novel therapeutic pathways.

Application

• Pharmaceutical Research & Development: A key intermediate and reference standard for developing kinase inhibitors targeting cancer, inflammation, and neurodegenerative diseases.
• Biochemical Studies: Used as a selective chemical probe to study cell cycle regulation, signal transduction pathways, and Wnt/β-catenin signaling in vitro.
• Natural Product Isolation & Analysis: Serves as a high-purity analytical standard for the quality control and identification of indirubin in traditional Chinese medicine formulations, such as Danggui Longhui Wan.
• Academic Research: Employed in university and institutional labs for fundamental research into the mechanisms of differentiation and apoptosis.
• Preclinical Studies: Investigated for its potential therapeutic effects in models of leukemia, psoriasis, and other proliferative disorders.

Basic Information

Product Name	Indirubin
CAS No.	479-41-4
Molecular Formula	C16H10N2O2
Molecular Weight	262.26 g/mol
Synonyms	Indirubin; 2,3'-Biindolin-2'-one; 3-(1,3-Dihydro-3-oxo-2H-indol-2-ylidene)-1,3-dihydro-2H-indol-2-one; Indigo Red; Couroupitine B; CI 75780; Indirubin B; [2,3'-Biindoline]-2'-one
EINECS	207-536-3

Quality Control

Our Indirubin is manufactured under a strict quality management system to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant research and development standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive and easily oxidized; for long-term storage, consider keeping the container under an inert atmosphere such as argon or nitrogen to maintain stability.

Specification

Item	Specification
Appearance	Red to reddish-brown powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.