Description

Cularine CAS NO 479-39-0 is a naturally occurring isoquinoline alkaloid of significant interest in pharmacological research and development. This compound serves as a valuable reference standard and a key intermediate for the synthesis of more complex bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies focused on neuroscience, cardiovascular studies, and the exploration of novel therapeutic agents.

Application

• Pharmacological Reference Standard: Used as a high-purity analytical standard in HPLC, LC-MS, and NMR for method development, validation, and quality control in research laboratories.
• Neuroscience Research: Investigated for its potential biological activity and interactions within neurological pathways, serving as a tool compound for target identification and validation.
• Medicinal Chemistry Intermediate: Acts as a sophisticated building block for the semi-synthesis of novel alkaloid derivatives and analogs with potential enhanced bioactivity.
• Academic & Institutional Research: Employed in universities and R&D centers for fundamental studies on plant alkaloids, their biosynthesis, and structure-activity relationships (SAR).
• Biochemical Assay Development: Utilized in the development and calibration of in vitro assays to screen for specific biological or enzymatic activities.

Basic Information

Product Name	Cularine
CAS No.	479-39-0
Molecular Formula	C20H21NO4
Molecular Weight	339.39 g/mol
Synonyms	Cularine; (+)-Cularine; (6aS,13aS)-5,6,6a,7,8,13a-Hexahydro-2,3,10,11-tetramethoxy-6-methyl-4H-dibenzo[de,g]quinoline-1,9-diol; 1,2,9,10-Tetramethoxy-6-methyl-5,6,6a,7,8,13a-hexahydro-4H-dibenzo[de,g]quinoline-4,13-dione (deprotonated form); Fumaricine (related alkaloid, often referenced)
EINECS	Contact for details

Quality Control

Our Cularine is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to relevant guidelines for reference standard materials to support your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.