Description

Ergoline-8-Carboxylic Acid, 2-Bromo-9,10-Didehydro-6-Methyl-, (8β)- is a high-purity, synthetic ergoline derivative, a crucial advanced intermediate in modern pharmaceutical research and development. This compound is valued for its role as a key building block in the synthesis of complex, biologically active molecules targeting neurological and cardiovascular pathways. It is primarily sought by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly within the fields of neurology and receptor-specific drug discovery.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex ergot alkaloid derivatives and other pharmacologically active compounds.
• Neurological Research: Used as a key scaffold in the research and development of ligands for serotonin (5-HT) and dopamine receptor systems.
• Medicinal Chemistry: Serves as a versatile building block for structure-activity relationship (SAR) studies and the creation of novel chemical libraries for high-throughput screening.
• Reference Standard: Employed as an analytical standard in quality control laboratories for the identification and quantification of related substances in active pharmaceutical ingredients (APIs).
• Process Development: Utilized in the scale-up and optimization of synthetic routes for target molecules in pre-clinical and clinical development stages.

Basic Information

Product Name	Ergoline-8-Carboxylic Acid, 2-Bromo-9,10-Didehydro-6-Methyl-, (8β)-
CAS No.	478-83-1
Molecular Formula	C₁₇H₁₇BrN₂O₂
Molecular Weight	361.24 g/mol
Synonyms	2-Bromolysergic Acid; 2-Bromo-9,10-didehydro-6-methylergoline-8β-carboxylic Acid; 2-Bromolysergate; (8β)-2-Bromo-9,10-didehydro-6-methylergoline-8-carboxylic Acid; 2-Bromo-D-Lysergic Acid; Bromolysergic Acid; 2-Bromoergoline-8-carboxylic Acid
EINECS	207-528-8

Quality Control

Our Ergoline-8-Carboxylic Acid, 2-Bromo-9,10-Didehydro-6-Methyl-, (8β)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.