Description

Demecolcine CAS NO 477-30-5 is a potent alkaloid compound derived from the autumn crocus (*Colchicum autumnale*), primarily recognized for its antimitotic properties. This high-purity active pharmaceutical ingredient (API) is critical for research and development in cell biology and oncology, where precise biological activity is paramount. It is essential for pharmaceutical manufacturers, academic research institutions, and biotechnology companies engaged in cell cycle studies, cytogenetics, and the development of novel therapeutic agents.

Application

• Cell Biology Research: Used as a mitotic inhibitor to arrest cells in metaphase for chromosome analysis (karyotyping).
• Oncology & Cancer Research: Investigated for its potential in studying cell cycle disruption and as a tool compound in anti-cancer drug discovery.
• Pharmaceutical Intermediates: Serves as a key starting material or intermediate in the synthesis of more complex pharmaceutical compounds.
• Biochemical Reagents: Employed in the formulation of high-grade biochemical reagents and assay kits for life science research.
• Academic & Clinical Laboratories: Essential for cytogenetic laboratories and research facilities studying cellular mechanisms and genetic disorders.

Basic Information

Product Name	Demecolcine
CAS No.	477-30-5
Molecular Formula	C21H25NO5
Molecular Weight	371.43 g/mol
Synonyms	Demecolcine; Deacetylcolchicine; Colcemid®; N-Deacetyl-N-methylcolchicine; Santavy's Substance F; O-Methylcolchicine; NSC 3096; (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide
EINECS	207-519-9

Quality Control

Our Demecolcine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines to support our clients' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.