Description

(+)-Corydaline CAS NO 476-69-7 is a high-purity, naturally occurring isoquinoline alkaloid isolated from plants of the *Corydalis* genus. This compound is of significant interest for its role as a key reference standard and active pharmaceutical ingredient (API) intermediate in research and development. It is primarily utilized by pharmaceutical companies, academic research institutions, and analytical laboratories focused on neuroscience, pharmacology, and natural product chemistry.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis of herbal extracts and finished pharmaceutical products in quality control laboratories.
• Neuroscience Research: Serves as a crucial biochemical tool for studying dopaminergic and serotonergic pathways, receptor binding, and enzyme inhibition assays.
• API Intermediate: Acts as a key chiral building block in the synthetic pathways for developing novel therapeutic agents.
• Natural Product Isolation & Standardization: Essential for the standardization and authentication of *Corydalis* species extracts used in traditional and modern medicine.
• Analytical Method Development: Employed as a known compound to develop and validate chromatographic methods like HPLC and LC-MS for alkaloid profiling.
• Pharmacological Screening: Used in high-throughput screening libraries to evaluate biological activity against various disease targets.

Basic Information

Product Name	(+)-Corydaline
CAS No.	476-69-7
Molecular Formula	C22H27NO4
Molecular Weight	369.46 g/mol
Synonyms	(+)-Corydaline; d-Corydaline; Corydaline; (13aS)-2,3,9,10-Tetramethoxy-13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline; 5H-Isoquinolino[2,1-b]isoquinoline, 2,3,9,10-tetramethoxy-13-methyl-6,8,13,13a-tetrahydro-, (13aS)-; NSC 169854
EINECS	207-517-5

Quality Control

Our (+)-Corydaline is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Specific Rotation	+311° to +321° (c=1 in CHCl3)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.