Description

Reserpin n-Oxide CAS NO 474-48-6 is a significant derivative of the alkaloid reserpine, representing a key intermediate and reference standard in pharmaceutical research and development. This compound is of critical importance for its role in metabolic pathway studies and the synthesis of related bioactive molecules. It is primarily utilized by pharmaceutical manufacturers, analytical laboratories, and academic research institutions engaged in cardiovascular and neurological drug discovery.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification and quantification of reserpine and its metabolites in quality control and regulatory testing.
• Drug Metabolism & Pharmacokinetics (DMPK) Studies: Serves as a crucial metabolite standard for investigating the biotransformation pathways, stability, and clearance of reserpine.
• Active Pharmaceutical Ingredient (API) Intermediate: Employed in the synthetic pathways for producing reserpine and structurally related therapeutic agents.
• Analytical Research: Essential for method development and validation in chromatographic (HPLC, LC-MS) analyses within pharmaceutical and bioanalytical laboratories.
• Biochemical Research: Used in studies exploring the mechanisms of action of rauwolfia alkaloids on neurotransmitter storage and release.

Basic Information

Product Name	Reserpin n-Oxide
CAS No.	474-48-6
Molecular Formula	C33H40N2O10
Molecular Weight	624.68 g/mol
Synonyms	Reserpine N-Oxide; Reserpinone N-Oxide; 11,17-Dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic acid methyl ester N-oxide; Reserpine Oxide; 3,4,5-Trimethoxybenzoyl reserpate N-oxide; Reserpin N-Oxide; Reserpine N-Oxyde
EINECS	Contact for details

Quality Control

Our Reserpin n-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis to ensure it meets the stringent requirements for research and reference standard applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specified parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.