Description

(1R,5S)-1,8,8-Trimethyl-3-Azabicyclo[3.2.1]Octane is a high-purity, stereochemically defined bicyclic amine, a key chiral building block in advanced organic synthesis. Its rigid, three-dimensional structure is critical for imparting specific biological activity and stereochemical control in complex molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and fine chemicals where precise spatial orientation is paramount.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of central nervous system (CNS) drugs and alkaloid-based therapeutics.
• Agrochemical Synthesis: Used as a building block for creating novel, stereoselective pesticides and herbicides with enhanced efficacy and environmental profiles.
• Catalyst Ligand Precursor: Serves as a starting material for the preparation of chiral ligands used in asymmetric catalysis, enabling the production of enantiomerically pure compounds.
• Fine Chemical & Flavor/Fragrance Intermediate: Employed in the synthesis of complex natural product analogs and specialty aroma chemicals.
• Academic & Industrial R&D: A valuable tool for methodological development in organic chemistry and for exploring new chemical spaces in drug discovery programs.

Basic Information

Product Name	(1R,5S)-1,8,8-Trimethyl-3-Azabicyclo[3.2.1]Octane
CAS No.	465-49-6
Molecular Formula	C10H19N
Molecular Weight	153.26 g/mol
Synonyms	(1R,5S)-1,8,8-Trimethyl-3-azabicyclo[3.2.1]octane; (1R,5S)-3-Azabicyclo[3.2.1]octane, 1,8,8-trimethyl-; (1R,5S)-Tropane; endo-1,8,8-Trimethyl-3-azabicyclo[3.2.1]octane; (1R,5S)-Nortropane; Tropane, (1R,5S)-; endo-Tropane; Bicyclo[3.2.1]octane, 1,8,8-trimethyl-3-aza-, (1R,5S)-
EINECS	Contact for details

Quality Control

Our (1R,5S)-1,8,8-Trimethyl-3-Azabicyclo[3.2.1]Octane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC and GC, to ensure it meets the high standards required for pharmaceutical and advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and enantiomeric excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.