Description

Hdmapp - 1-Hydroxy-2-Methyl-2-Buten-4-Yl 4-Diphosphate is a high-purity, synthetic phosphoantigen compound of significant interest in immunological research and pharmaceutical development. This molecule serves as a critical intermediate and a potent activator of Vγ9Vδ2 T cells, a unique subset of human gamma delta T lymphocytes. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel immunotherapies, including treatments for cancer and infectious diseases.

Application

• Immunotherapy Research: As a potent phosphoantigen for activating human Vγ9Vδ2 T cells in vitro and in vivo studies.
• Drug Discovery: A key intermediate in the synthesis of next-generation immunomodulatory drugs and small molecule vaccine adjuvants.
• Cell-Based Assays: Used to stimulate gamma delta T cells in functional assays to study cytotoxicity, cytokine production, and proliferation.
• Preclinical Development: Evaluation of efficacy and mechanism of action in animal models of cancer and infection.
• Biochemical Reagent: Serves as a high-purity reference standard and reagent in biochemical and pharmacological research.
• Academic Research: Fundamental studies on the biology of gamma delta T cells and innate-like lymphocyte responses.

Basic Information

Product Name	Hdmapp - 1-Hydroxy-2-Methyl-2-Buten-4-Yl 4-Diphosphate
CAS No.	396726-03-7
Molecular Formula	C5H12O8P2
Molecular Weight	262.09 g/mol
Synonyms	(E)-4-Hydroxy-3-methylbut-2-en-1-yl diphosphate; HDMAPP; Hydroxymethylbutenyl diphosphate; (E)-1-Hydroxy-2-methyl-2-buten-4-yl diphosphate; BrHPP isomer; Phosphostim analogue; Vγ9Vδ2 T cell antigen; Isopentenyl pyrophosphate analogue
EINECS	Contact for details

Quality Control

Our Hdmapp is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant guidelines for the production of research-grade biochemicals to support reliable and reproducible scientific outcomes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep desiccated at -80°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.