Description

(2R,5R)-(+)-2-tert-Butyl-3-Methyl-5-Benzyl-4-Imidazolidinone is a high-value, enantiomerically pure organocatalyst belonging to the imidazolidinone class. This compound matters as a powerful chiral auxiliary and catalyst, enabling the asymmetric synthesis of complex molecules with high stereoselectivity. It is critically needed by R&D and production teams in the pharmaceutical, agrochemical, and fine chemical industries for developing novel active ingredients and advanced intermediates.

Application

• Asymmetric Organocatalysis: Employed as a key catalyst in enantioselective reactions such as Diels-Alder, Friedel-Crafts alkylations, and 1,3-dipolar cycloadditions.
• Pharmaceutical Intermediate Synthesis: Used in the stereocontrolled construction of chiral centers for active pharmaceutical ingredients (APIs), including those for cardiovascular and central nervous system drugs.
• Agrochemical Development: Facilitates the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Chiral Auxiliary in Medicinal Chemistry: Serves as a temporary stereodirecting group to control the absolute configuration in multi-step synthetic routes.
• Fine Chemical and Fragrance Production: Applied in the synthesis of high-value chiral flavor and fragrance compounds.
• Academic and Industrial R&D: A vital tool for methodological development in asymmetric synthesis and process chemistry optimization.

Basic Information

Product Name	(2R,5R)-(+)-2-tert-Butyl-3-Methyl-5-Benzyl-4-Imidazolidinone
CAS No.	390766-89-9
Molecular Formula	C₁₅H₂₁N₂O
Molecular Weight	245.34 g/mol
Synonyms	(2R,5R)-2-tert-Butyl-3-methyl-5-benzylimidazolidin-4-one; (2R,5R)-tert-Butylmethylbenzylimidazolidinone; MacMillan Catalyst First Generation; (2R,5R)-5-Benzyl-2-tert-butyl-3-methyl-4-imidazolidinone; (R,R)-2-tert-Butyl-3-methyl-5-benzyl-4-imidazolidinone; (R,R)-tert-Butylmethylbenzylimidazolidinone; (2R,5R)-Imidazolidinone Organocatalyst
EINECS	Contact for details

Quality Control

Our (2R,5R)-(+)-2-tert-Butyl-3-Methyl-5-Benzyl-4-Imidazolidinone is manufactured under strict quality systems to ensure batch-to-batch consistency and high enantiomeric purity. Quality is verified through comprehensive analytical techniques including HPLC, chiral chromatography, and NMR. A Certificate of Analysis (COA) detailing purity, enantiomeric excess (ee), and identity is provided with each shipment, supporting cGMP and ISO 9001 compliant workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.