Description

H-Lys-Ala-Pna is a high-purity synthetic peptide derivative, specifically a para-nitroanilide (PNA) substrate. This compound is a critical biochemical tool for enzymatic activity studies, particularly for proteases and peptidases. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require precise, reliable substrates for assay development, high-throughput screening, and enzyme kinetics research.

Application

• Protease/Peptidase Substrate: Used as a chromogenic substrate for the kinetic analysis and characterization of serine and cysteine proteases.
• Biochemical Assay Development: A key reagent in designing and optimizing in vitro enzymatic assays for drug discovery pipelines.
• High-Throughput Screening (HTS): Employed in automated screening platforms to identify and validate potential enzyme inhibitors or activators.
• Enzyme Mechanism Studies: Facilitates research into enzyme specificity, catalytic efficiency, and inhibition mechanisms.
• Diagnostic Reagent Manufacturing: Serves as a component in the production of diagnostic kits for detecting specific enzymatic activities.
• Academic & Industrial Research: Supports fundamental and applied research in biochemistry, molecular biology, and medicinal chemistry.

Basic Information

Product Name	H-Lys-Ala-Pna
CAS No.	390366-87-7
Molecular Formula	C19H29N7O5
Molecular Weight	459.48 g/mol
Synonyms	L-Lysyl-L-alanine 4-nitroanilide; Lys-Ala-pNA; H-Lys-Ala-pNA; Nα-Benzyloxycarbonyl-L-lysyl-L-alanine 4-nitroanilide; Z-Lys-Ala-pNA; Substrate for Lys-Ala specific proteases; Peptide substrate 390366-87-7; L-Lysine, L-alanine, 4-nitroanilide derivative
EINECS	Contact for details

Quality Control

Our H-Lys-Ala-Pna is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification, to ensure it meets the exacting standards required for research and diagnostic applications. A Certificate of Analysis (COA) detailing purity, identity, and other critical parameters is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain purity and activity. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.