Description

[1-(Trimethylammonium)Methyl] Methanethiosulfonate Bromide is a specialized organosulfur compound with a reactive methanethiosulfonate (MTS) group, widely used as a versatile bioconjugation and protein modification reagent. Its core value lies in its ability to selectively modify cysteine residues, enabling controlled cross-linking, site-directed spin labeling, and the introduction of functional groups into biomolecules. This product is essential for researchers and manufacturers in pharmaceutical development, proteomics, and structural biology who require high-purity, reliable reagents for advanced biochemical applications.

Application

• Site-Directed Spin Labeling (SDSL): A key reagent for introducing paramagnetic spin labels onto specific cysteine residues in proteins for Electron Paramagnetic Resonance (EPR) spectroscopy studies.
• Protein Cross-Linking and Conjugation: Used to create disulfide bridges or attach fluorophores, biotin, or other probes to proteins and peptides for functional and structural analysis.
• Membrane Protein Studies: Facilitates the labeling and investigation of cysteine residues in challenging membrane protein systems.
• Bioconjugation for Drug Discovery: Enables the controlled attachment of payloads, linkers, or targeting moieties in the development of antibody-drug conjugates (ADCs) and other biotherapeutics.
• Structural Biology Tool: Employed in probing protein dynamics, folding, and protein-protein interactions through distance measurements.
• Surface Immobilization Chemistry: Used to functionalize surfaces with thiol-reactive groups for biosensor development and microarray fabrication.

Basic Information

Product Name	[1-(Trimethylammonium)Methyl] Methanethiosulfonate Bromide
CAS No.	386229-81-8
Molecular Formula	C5H12BrNO2S2
Molecular Weight	262.19 g/mol
Synonyms	(Trimethylammonio)methyl methanethiosulfonate bromide; MTSL precursor; 1-(Trimethylammonium)methyl methanethiosulfonate bromide; Methanethiosulfonate spin label reagent; (3-(Methanethiosulfonyl)propyl)trimethylammonium bromide (common related structure); MTSSL amine precursor; Protein cysteine modification reagent; Thiol-reactive MTS reagent; S-(2-Trimethylammoniumethyl)methanethiosulfonate bromide (alternative naming); TAMMTS bromide
EINECS	Contact for details

Quality Control

Our [1-(Trimethylammonium)Methyl] Methanethiosulfonate Bromide is manufactured under strict quality systems to ensure batch-to-batch consistency and high reactivity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to rigorous analytical standards, utilizing techniques such as NMR, HPLC, and mass spectrometry to verify product integrity for sensitive research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.