Description

Sodium (5-Sulfonatopentyl) Methanethiosulfonate is a specialized, water-soluble chemical reagent featuring a reactive methanethiosulfonate group linked to a sulfonated alkyl chain. This compound matters for its ability to serve as a highly specific and efficient sulfhydryl-reactive crosslinker or labeling agent in aqueous systems, enabling precise protein modification and conjugation. It is primarily needed by researchers and manufacturers in the life sciences, particularly for applications in bioconjugation, antibody-drug conjugate (ADC) development, and the site-specific modification of proteins and peptides.

Application

• Bioconjugation Reagent: For the site-specific covalent attachment of labels, drugs, or other molecules to cysteine residues in proteins and antibodies.
• Antibody-Drug Conjugate (ADC) Linker Chemistry: As a functional component in the development of stable, cleavable linkers for targeted cancer therapies.
• Protein Crosslinking: Used to create intramolecular or intermolecular disulfide bridges or thioether bonds for structural studies or stabilization.
• Surface Functionalization: Modification of gold nanoparticles or other surfaces via thiol-gold chemistry for biosensor and diagnostic assay development.
• Peptide Modification: Selective tagging or cyclization of synthetic peptides containing free thiol groups.
• Enzyme Immobilization: Covalent attachment of enzymes to solid supports while aiming to preserve activity, facilitated by its hydrophilic sulfonate group.
• Polymer Chemistry: As a functional monomer or modifier to introduce reactive thiol or sulfonate groups into polymeric materials.

Basic Information

Product Name	Sodium (5-Sulfonatopentyl) Methanethiosulfonate
CAS No.	385398-80-1
Molecular Formula	C7H13NaO5S3
Molecular Weight	320.40 g/mol
Synonyms	MTS-Sulfonate; Sodium 5-((Methylsulfonyl)thio)pentane-1-sulfonate; (5-Sulfonatopentyl) Methanethiosulfonate Sodium Salt; MTSSL Sulfonate; S-Methyl 5-Sulfonatopentyl Methanethiosulfonate; Sulfonated MTS Reagent; Water-soluble Methanethiosulfonate; 5-(Methanethiosulfonato)pentylsulfonic Acid Sodium Salt
EINECS	Contact for details

Quality Control

Our Sodium (5-Sulfonatopentyl) Methanethiosulfonate is produced under stringent quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and NMR for structural confirmation, to ensure compliance with high-purity research-grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture. For long-term storage, consider desiccant or under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Freely soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.