Description

Sodium (4-Sulfonatobutyl)Methanethiosulfonate is a specialized, water-soluble thiol-reactive reagent used for site-specific protein and peptide modification. This compound is valued for its ability to introduce a stable, negatively charged sulfonate group onto cysteine residues, which can alter solubility and prevent disulfide bond formation. It is primarily needed by researchers and manufacturers in the fields of bioconjugation, protein engineering, and diagnostic assay development, where precise chemical labeling is critical.

Application

• Bioconjugation Reagent: For the site-specific labeling of antibodies, enzymes, and other proteins at cysteine residues.
• Protein Modification & Engineering: To introduce negative charges or hydrophilic linkers onto proteins to alter their physicochemical properties.
• Diagnostic Assay Development: Used in the preparation of enzyme conjugates and labeled antigens/antibodies for immunoassays (e.g., ELISA).
• Surface Functionalization: For modifying gold nanoparticles or biosensor surfaces with thiol-reactive groups to create stable, oriented protein layers.
• Cross-linking Studies: As a reversible or cleavable cross-linker in structural biology and protein interaction analysis.
• Therapeutic Protein Development: In the PEGylation or functionalization of therapeutic peptides and proteins to improve stability and pharmacokinetics.

Basic Information

Product Name	Sodium (4-Sulfonatobutyl)Methanethiosulfonate
CAS No.	385398-78-7
Molecular Formula	C5H11NaO5S3
Molecular Weight	278.33 g/mol
Synonyms	Sodium 4-(Methanethiosulfonato)butane-1-sulfonate; MTSES Sodium Salt; (4-Sulfonatobutyl) Methanethiosulfonate Sodium Salt; Sodium (4-Sulfobutyl) Methanethiosulfonate; MTSEA-Sulfonate; S-Methyl methanethiosulfonate sulfobutyl sodium salt; Thiol-reactive sulfonate reagent; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our Sodium (4-Sulfonatobutyl)Methanethiosulfonate is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry, to ensure it meets the high standards required for research and bioconjugation applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccant.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Freely soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.