Description

1,2-Dioleoyl-Sn-Glycero-3-Phosphoethanolamine-n-[4-(p-Maleimidomethyl)Cyclohexane-Carboxamide] (Sodium Salt) is a high-purity, functionalized phospholipid derivative designed for advanced bioconjugation and drug delivery applications. Its core value lies in the maleimide functional group, which enables site-specific covalent coupling to thiol-containing molecules like peptides, proteins, and antibodies under mild physiological conditions. This product is essential for researchers and manufacturers in pharmaceutical development, nanotechnology, and diagnostic assay creation, particularly for constructing targeted liposomes, lipid nanoparticles (LNPs), and other sophisticated biomaterials.

Application

• Targeted Drug Delivery Systems: Covalent attachment of targeting ligands (e.g., antibodies, peptides) to the surface of liposomes and lipid nanoparticles (LNPs) for cancer therapy and other targeted treatments.
• Bioconjugation & Protein Labeling: Site-specific coupling to cysteine residues on proteins, antibodies, or enzymes for creating stable conjugates used in diagnostics, imaging, and therapeutics.
• Lipid Membrane Functionalization: Incorporation into lipid bilayers to introduce reactive handles for surface modification of vesicles, cell membranes, or biosensors.
• mRNA Vaccine & Gene Therapy Platforms: As a component in ionizable lipid mixtures for LNPs to enable surface PEGylation or the attachment of targeting moieties, enhancing stability and cell-specific delivery.
• Diagnostic Reagent Development: Creating stable immunoassays and fluorescent probes by linking detection molecules to carrier lipids or particles.
• Biomaterial Surface Engineering: Modifying surfaces with reactive lipid layers to control cell adhesion, protein immobilization, and biosensor interface properties.
• Research Grade Reagent: Used in academic and industrial R&D for studying membrane biophysics, drug encapsulation, and novel nanoparticle formulations.

Basic Information

Product Name	1,2-Dioleoyl-Sn-Glycero-3-Phosphoethanolamine-n-[4-(p-Maleimidomethyl)Cyclohexane-Carboxamide] (Sodium Salt)
CAS No.	384847-49-8
Molecular Formula	C85H153N2NaO11P
Molecular Weight	1440.13 g/mol (approx.)
Synonyms	DOPE-MCC; Maleimide-DOPE; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine-N-[4-(p-maleimidomethyl)cyclohexane-carboxamide] sodium salt; MCC-PE; PE-MCC; Maleimidocaproyl-DOPE; 18:1 PE-MCC; Functionalized DOPE; N-[(4-Maleimidomethyl)cyclohexanecarbonyl]-1,2-dioleoyl-sn-glycero-3-phosphoethanolamine sodium salt
EINECS	Contact for details

Quality Control

Our 1,2-Dioleoyl-Sn-Glycero-3-Phosphoethanolamine-n-[4-(p-Maleimidomethyl)Cyclohexane-Carboxamide] (Sodium Salt) is manufactured under strict quality systems to ensure batch-to-batch consistency and high performance in sensitive bioconjugation applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to meet exacting research and cGMP-grade standards where applicable. A comprehensive Certificate of Analysis (COA) detailing purity, functional activity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake. For long-term storage, keep containers in a dry, inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95% (Area %)
Functional Assay (Maleimide)	≥ 90% of theoretical
Solubility	Soluble in chloroform, ethanol, DMSO; forms micelles in aqueous buffer
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.