Description

1,2-Dioleoyl-Sn-Glycero-3-Phosphoethanolamine-n-(Cap Biotinyl) (Sodium Salt) is a high-purity, synthetic phospholipid derivative, critically engineered for advanced bioconjugation and targeted delivery applications. Its core value lies in the precise functionalization with a biotin cap, enabling strong, specific binding to avidin or streptavidin for sophisticated research and diagnostic platforms. This compound is essential for researchers and formulators in pharmaceutical development, lipid nanoparticle (LNP) technology, and molecular diagnostics who require reliable, well-characterized building blocks for complex assemblies.

Application

• Lipid Nanoparticle (LNP) Formulation: As a functionalized, PEG-free component for creating targeted drug delivery systems, particularly for nucleic acid therapeutics.
• Biotin-Avidin/Streptavidin Technology: A key reagent for immobilizing liposomes, micelles, or other lipid-based structures onto surfaces coated with (strept)avidin for biosensors, assays, and affinity purification.
• Membrane Protein Research: Used in the reconstitution and study of membrane proteins, where biotinylation allows for specific capture and analysis.
• Diagnostic Assay Development: Incorporation into liposomal or micellar carriers for signal amplification in immunoassays and lateral flow tests.
• Targeted Imaging Probes: A building block for constructing contrast agent carriers (e.g., for MRI or fluorescence) that can be directed to specific biological sites.
• Model Membrane Studies: Employed in biophysical research to create functionalized lipid bilayers with specific binding properties.

Basic Information

Product Name	1,2-Dioleoyl-Sn-Glycero-3-Phosphoethanolamine-n-(Cap Biotinyl) (Sodium Salt)
CAS No.	384835-51-2
Molecular Formula	C89H162N4NaO11P
Molecular Weight	~1542.2 g/mol
Synonyms	Biotin Cap PE; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine-N-(cap biotinyl) (sodium salt); Biotinyl Cap Phosphatidylethanolamine; DOPE-Biotin (Cap); Biotin-Cap-DOPE; N-(Biotinoyl)-1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, sodium salt; 18:1 Biotinyl Cap PE; Biotinylated DOPE
EINECS	Contact for details

Quality Control

Every batch of our 1,2-Dioleoyl-Sn-Glycero-3-Phosphoethanolamine-n-(Cap Biotinyl) (Sodium Salt) is produced and tested under stringent quality management systems. We provide comprehensive analytical data to ensure identity, purity, and functional performance for critical research and GMP-grade applications. A detailed Certificate of Analysis (COA) including HPLC purity, MS confirmation, and functional assay results is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below under an inert atmosphere (e.g., argon or nitrogen). Under these conditions, the product is typically stable for at least 24 months. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (MS)	Complies
Identification (NMR)	Complies
Purity (HPLC)	≥ 95.0%
Solubility	Soluble in chloroform, ethanol; forms micelles in aqueous buffer
Residual Solvents (GC)	Meets ICH guidelines
Biotin Content (Functional Assay)	≥ 85% of theoretical
Water Content (KF)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.