Description

1,2-Dioleoyl-Sn-Glycero-3-Phosphoethanolamine-n-[4-(p-Maleimidophenyl)Butyramide] (Sodium Salt) is a high-purity, functionalized phospholipid derivative designed for advanced bioconjugation and drug delivery applications. Its core value lies in the maleimide functional group, which enables specific, covalent coupling to thiol-containing molecules under mild physiological conditions. This product is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing targeted liposomal formulations, antibody-drug conjugates (ADCs), and other sophisticated nanocarrier systems.

Application

• Liposome and Lipid Nanoparticle (LNP) Functionalization: Covalent attachment of targeting ligands (e.g., antibodies, peptides) or therapeutic payloads to the surface of nanocarriers for active drug targeting.
• Antibody-Drug Conjugate (ADC) Linker Chemistry: Serves as a heterobifunctional linker component for constructing stable, cleavable, or non-cleavable linkages between antibodies and cytotoxic drugs.
• Surface Modification of Biomaterials: Creating maleimide-activated surfaces on polymers, hydrogels, or microspheres for the controlled immobilization of proteins, enzymes, or cells.
• Protein and Peptide Labeling: Site-specific conjugation of lipids, fluorophores, or other probes to cysteine residues within proteins for diagnostic or tracking applications.
• Stimuli-Responsive Nanocarrier Development: Integration into liposomal membranes to create systems that release cargo in response to specific biological triggers.
• Long-Circulating "Stealth" Liposome Engineering: Used in conjunction with PEGylated lipids to create multifunctional, long-circulating nanoparticles with targeting capabilities.

Basic Information

Item	Details
Product Name	1,2-Dioleoyl-Sn-Glycero-3-Phosphoethanolamine-n-[4-(p-Maleimidophenyl)Butyramide] (Sodium Salt)
CAS No.	384835-49-8
Molecular Formula	C85H147N2O11PNa
Molecular Weight	~1386.0 g/mol
Synonyms	DOPE-MPB; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine-N-[4-(p-maleimidophenyl)butyramide] sodium salt; MPB-DOPE; Maleimide-PEG-DOPE; N-[4-(p-Maleimidophenyl)butyryl]-1,2-dioleoyl-sn-glycero-3-phosphoethanolamine sodium salt; Maleimide-functionalized DOPE; Heterobifunctional DOPE linker; 18:1 MPB PE
EINECS	Contact for details

Quality Control

Our 1,2-Dioleoyl-Sn-Glycero-3-Phosphoethanolamine-n-[4-(p-Maleimidophenyl)Butyramide] (Sodium Salt) is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for critical research and GMP-grade applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and functional activity. We adhere to stringent analytical protocols, including HPLC, NMR, and mass spectrometry, to verify chemical structure and confirm the integrity of the maleimide functional group. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Under these conditions, the material is typically stable for at least 24 months. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95% (Area %)
Assay (Functional Maleimide)	≥ 90%
Solubility	Soluble in chloroform, DMSO; forms micelles in aqueous buffer
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.