Description

2-[3-(1-Pyrenyl)Propylcarboxamido]Ethyl Methanethiosulfonate is a specialized bifunctional chemical reagent designed for site-specific protein and biomolecule labeling. This compound matters because it combines a pyrene fluorophore for sensitive detection with a methanethiosulfonate (MTS) reactive group for selective, covalent modification of cysteine residues. Researchers and developers in the life sciences and pharmaceutical industries need it for advanced applications in bioconjugation, fluorescence-based assays, and the study of protein structure and function.

Application

• Site-Directed Spin Labeling (SDSL) in Electron Paramagnetic Resonance (EPR) spectroscopy for studying protein dynamics and conformational changes.
• Fluorescent Labeling of Proteins and Peptides for tracking, localization, and interaction studies via fluorescence spectroscopy or microscopy.
• Bioconjugation and Crosslinking for creating stable, defined linkages between biomolecules and surfaces or other probes.
• Cysteine-Specific Protein Modification for introducing spectroscopic probes or functional groups with high selectivity.
• Development of Diagnostic Assays and biosensors that utilize the pyrene moiety's fluorescence properties.
• Structural Biology Research, including mapping solvent accessibility and monitoring folding/unfolding events.
• Material Science for functionalizing surfaces with biomimetic or bioactive layers.

Basic Information

Product Name	2-[3-(1-Pyrenyl)Propylcarboxamido]Ethyl Methanethiosulfonate
CAS No.	384342-66-9
Molecular Formula	C25H23NO3S2
Molecular Weight	457.58 g/mol
Synonyms	MTSL-Pyrene; 1-Pyrenebutyric acid N-(2-((methylsulfonyl)thio)ethyl)amide; Pyrene-MTS; (1-Pyrenyl)-MTS; N-[2-[(Methylsulfonyl)thio]ethyl]-4-(1-pyrenyl)butyramide; Pyrene methanethiosulfonate; Pyrene labeling reagent; Cysteine-reactive pyrene probe
EINECS	Contact for details

Quality Control

Our 2-[3-(1-Pyrenyl)Propylcarboxamido]Ethyl Methanethiosulfonate is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity verification and spectroscopic methods for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed batch-specific data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. For long-term stability, store under inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to light brown solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.