Description

n-Palmitoyl-1-Deoxysphinganine (M18:0/16:0) is a specific, high-purity sphingolipid metabolite and a key intermediate in the study of deoxysphinganine-based ceramide analogs. This compound matters for researchers and developers in the life sciences sector as it provides a defined molecular tool for investigating cellular signaling pathways, lipid metabolism disorders, and the biochemical mechanisms underlying conditions like hereditary sensory neuropathy type 1 (HSAN1). It is primarily needed by pharmaceutical R&D teams, academic research institutions, and diagnostic developers focused on lipidomics, biomarker discovery, and the development of novel therapeutic agents targeting sphingolipid-related diseases.

Application

• Biomedical Research: Used as a critical standard and reference compound in lipidomics and metabolomics studies to identify and quantify related sphingolipid species in biological samples.
• Drug Discovery & Development: Serves as a key intermediate or pharmacological tool for synthesizing and testing novel ceramide analogs and inhibitors targeting sphingolipid metabolism pathways.
• Disease Mechanism Studies: Essential for in vitro and in vivo research into the role of atypical deoxysphingolipids in diabetic neuropathy, HSAN1, and other metabolic disorders.
• Diagnostic Assay Development: Employed as a calibrant or control in the development of LC-MS/MS-based clinical diagnostic assays for measuring pathogenic sphingolipids.
• Cell Biology & Signaling: Applied in cell culture studies to elucidate the effects of deoxysphinganine derivatives on apoptosis, cell proliferation, and stress responses.
• Biochemical Reagent: Functions as a substrate or inhibitor for enzymes involved in sphingolipid synthesis and degradation, such as serine palmitoyltransferase (SPT).

Basic Information

Product Name	n-Palmitoyl-1-Deoxysphinganine (M18:0/16:0)
CAS No.	378755-69-2
Molecular Formula	C₃₄H₆₉NO₂
Molecular Weight	523.93 g/mol
Synonyms	1-Deoxysphinganine C16:0; N-Palmitoyl-deoxysphinganine; N-[(2S,3R)-2-Amino-3-hydroxyoctadecyl]hexadecanamide; Deoxysphinganine palmitate; M18:0/16:0 Ceramide analog; 1-Deoxy-sphinganine C16:0; Atypical sphingolipid M18; 2-Amino-3-hydroxyoctadecyl palmitamide
EINECS	Contact for details

Quality Control

Our n-Palmitoyl-1-Deoxysphinganine is produced under stringent quality management systems. Each batch undergoes comprehensive analytical characterization using techniques including HPLC, MS, and NMR to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, identity confirmation, and impurity profiles are available upon request to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, ethanol, chloroform

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.