Description

S-Acetylthioglycolic Acid NHS Ester is a highly reactive, heterobifunctional crosslinking reagent designed for bioconjugation. This compound is critical for creating stable amide bonds between molecules containing primary amines and thiol groups, enabling precise protein and peptide modification. It is an essential tool for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing antibody-drug conjugates (ADCs), diagnostic probes, and advanced biomaterials.

Application

• Antibody-Drug Conjugate (ADC) Development: A key reagent for site-specific conjugation of cytotoxic payloads to monoclonal antibodies via thiol groups.
• Protein Labeling & Immobilization: Used to attach fluorescent dyes, biotin, or other probes to proteins for detection, imaging, and assay development.
• Peptide Synthesis & Modification: Facilitates the introduction of functional handles or crosslinks into synthetic peptides for therapeutic or research applications.
• Surface Functionalization: Enables the covalent attachment of biomolecules to sensor chips, nanoparticles, and other solid supports for biosensors and diagnostic devices.
• Polymer & Biomaterial Science: Serves as a crosslinker for synthesizing hydrogels and functional polymers with tailored biological activity.
• Diagnostic Reagent Manufacturing: Used in the production of enzyme conjugates and other critical components for immunoassay kits.

Basic Information

Product Name	S-Acetylthioglycolic Acid NHS Ester
CAS No.	374795-01-4
Molecular Formula	C8H9NO5S
Molecular Weight	231.22 g/mol
Synonyms	N-Hydroxysuccinimide S-acetylthioglycolate; SATA NHS Ester; N-Succinimidyl S-Acetylthioacetate; Acetylthioglycolic Acid N-Hydroxysuccinimide Ester; 2-[(Acetylthio)acetyl]oxy-2,5-pyrrolidinedione; S-Acetylmercaptoacetic Acid N-Succinimidyl Ester; NHS-SATA; S-Acetylthioglycolic Acid Active Ester
EINECS	Contact for details

Quality Control

Our S-Acetylthioglycolic Acid NHS Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a dry environment before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.