Description

Bis-n-Succinimidyl Diglycolic Acid, 2,2-Oxydiacetic Acid Bis-n-Succinimidyl Ester is a high-purity, homobifunctional N-hydroxysuccinimide (NHS) ester crosslinker. This compound is specifically engineered to facilitate the efficient and stable conjugation of biomolecules, such as proteins and peptides, through primary amine groups. It is an essential reagent for researchers and manufacturers in the fields of bioconjugation, antibody-drug conjugate (ADC) development, and diagnostic assay formulation, where reliable and specific crosslinking is paramount.

Application

• Bioconjugation and Protein Labeling: Primary reagent for covalently linking proteins, antibodies, or peptides to other molecules, surfaces, or carriers.
• Antibody-Drug Conjugate (ADC) Synthesis: Used as a linker to attach cytotoxic payloads to monoclonal antibodies for targeted cancer therapies.
• Diagnostic Assay Development: Critical for immobilizing capture antibodies or conjugating detection enzymes/fluorophores in ELISA, lateral flow, and other immunoassays.
• Biomaterial and Surface Functionalization: Enables the modification of polymers, nanoparticles, and sensor surfaces with bioactive molecules.
• Peptide Synthesis and Modification: Employed to crosslink peptides or introduce functional handles during solid-phase peptide synthesis.
• Affinity Chromatography Ligand Coupling: Facilitates the stable attachment of proteins or other ligands to chromatographic resin supports.

Basic Information

Product Name	Bis-n-Succinimidyl Diglycolic Acid, 2,2-Oxydiacetic Acid Bis-n-Succinimidyl Ester
CAS No.	373614-12-1
Molecular Formula	C14H14N2O10
Molecular Weight	370.27 g/mol
Synonyms	BS(PEG)2; Bis(N-succinimidyl) diglycolate; Diglycolic acid bis(N-succinimidyl) ester; 2,2'-Oxydiacetic acid bis(2,5-dioxopyrrolidin-1-yl) ester; NHS-PEG2-NHS; 1,1'-(Oxydi-2,1-ethanediyl)bis-1H-pyrrole-2,5-dione; Homobifunctional NHS-PEG crosslinker; BS(PEG)2 Crosslinker
EINECS	Contact for details

Quality Control

Our Bis-n-Succinimidyl Diglycolic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, IR), to ensure it meets the high standards required for sensitive bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.